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GC-C Agonists

GC-C or guanylate cyclase-C agonists are used to treat irritable bowel syndrome and chronic constipation. They work by increasing an enzyme in the lining of the intestine, which in turn helps speed up transit through the intestine and reduce intestinal pain.

Why are gc c agonists prescribed?

  1. Constipation (53%)
  2. Irritable Bowel Syndrome (47%)

Key takeaways

GC-C agonists are used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. Some GC-C agonists can also manage functional constipation in children. These medications work by activating guanylate cyclase-C receptors in your intestines, which helps increase fluid secretion and speed up bowel movements. They're available in oral form. Examples include Linzess (linaclotide) and Trulance (plecanatide). You can take these medications as prescribed to help manage your symptoms effectively.

Prices for popular GC-C Agonists medications
Viewing 2 of 2 medications
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Linzess

as low as$277
Linzess (linaclotide) treats irritable bowel syndrome (IBS) with constipation. It may also treat chronic constipation. Linzess is a GC-C agonist which works speeding up transit through the intestine. The most common form of Linzess is a 145mcg tablet. It is also avalible as a 72mcg tablet and a 290mcg tablet. There are currently no generic alterantives for Linzess. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Trulance

as low as$568
PLECANATIDE treats irritable bowel syndrome (IBS) with constipation. It may also treat chronic constipation. It works by softening the stool, making it easier to have a bowel movement.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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