Key takeaways
Linzess (linaclotide) and Trulance (plecanatide) are both medications used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). They belong to the same drug class, guanylate cyclase-C (GC-C) agonists, and work by increasing fluid in the intestines to help with bowel movements and relieve stomach pain. Both medications are available only as a brand medication. Linzess must be taken on an empty stomach at least 30 minutes before a meal, whereas Trulance can be taken with or without food at any time of the day. Both medications can cause diarrhea, but Linzess has a higher reported rate of this side effect. Additionally, Linzess is approved for use in children ages 6 to 17 for functional constipation, while Trulance is not recommended for anyone under 18 years old. Both medications have serious warnings about the risk of dehydration, especially in young children.
