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Compare Ibsrela vs. Linzess

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ibsrela (tenapanor) and Linzess (linaclotide) are both used to treat irritable bowel syndrome with constipation (IBS-C) in adults, but they work in different ways. Ibsrela is a sodium/hydrogen exchanger 3 (NHE3) inhibitor that prevents sodium absorption in the gut, which helps soften stool and relieve stomach pain. It also works on the nerves in the gut to help relieve stomach pain. Ibsrela is taken twice a day before meals. Linzess, on the other hand, is a guanylate cyclase-C (GC-C) agonist that increases fluid in the intestines and speeds up food movement through the gut. You take it once a day on an empty stomach. Additionally, Linzess is also used to treat chronic idiopathic constipation (CIC) in adults as well as functional constipation (FC) in children, whereas Ibsrela is not recommended for children. Both medications can cause diarrhea, stomach bloating, and gas and are only available as a brand medication.

  • Ibsrela (tenapanor)
    Linzess (linaclotide)
  • Ibsrela (tenapanor)
    Linzess (linaclotide)

  • Summary of Ibsrela vs. Linzess

    Summary for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Prescription only

    Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.

    Summary for GC-C agonist
    Prescription only

    Linzess (linaclotide) is a medication that can help with long-lasting constipation. It's approved for adults with constipation from irritable bowel syndrome (IBS) or other unknown reasons. It's also for children ages 6 to 17 who have functional constipation. Linzess (linaclotide) belongs to a drug class called guanylate cyclase-C agonists. It's a capsule that you take by mouth once a day. Diarrhea is a common side effect. Right now, Linzess (linaclotide) is only available as a brand-name medication. There's no generic version yet.

  • Indications of Ibsrela vs. Linzess

    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults
    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults
    •Chronic idiopathic constipation (CIC) in adults
    •Functional constipation (FC) in children between 6 and 17 years old

  • Pros and Cons of Ibsrela vs. Linzess

    Pros and Const for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Pros
    •Recommended for people with IBS-C who've already tried other therapies
    •Can help lessen episodes of stomach pain and constipation
    •Symptoms can start to improve within a week
    Cons
    •Need to take right before a meal twice daily
    •Can cause diarrhea and dehydration
    •Not safe for children
    Pros and Const for GC-C agonist
    Pros
    •Only need to take once a day
    •Can start to see improvement as early as a week of taking it every day
    Cons
    •Must take on an empty stomach (30 minutes before a meal)
    •Can cause diarrhea

  • Common Side Effects of Ibsrela vs. Linzess

    Common Side Effects for
    •Diarrhea (16%)
    •Stomach bloating (3%)
    •Gas (3%)
    •Dizziness (2%)
    Common Side Effects for

    Adults Note: Side effects reported for IBS-C. Side effects might differ for CIC. <br>

    •Diarrhea (20%)
    •Stomach pain (7%)
    •Having gas (4%)
    •Bloating and feeling full in the belly (2%)

    Children

    •Diarrhea (4%)

  • Warnings of Ibsrela vs. Linzess

    Common Side Effects for
    •Serious dehydration in children
    •Diarrhea
    Common Side Effects for
    •Not for children younger than 2 years of age because of risk of serious dehydration
    •Severe diarrhea

  • Prices with our coupons for Ibsrela vs. Linzess

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