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NHE3 Inhibitors

NHE3 Inhibitors are used to treat irritable bowel syndrome. They work by reducing the absorption of sodium from the small intestine, resulting in easier stool passing.

Why are nhe3 inhibitors prescribed?

  1. Constipation (50%)
  2. Irritable Bowel Syndrome (50%)
  3. Hyperphosphatemia (0%)

Key takeaways

NHE3 inhibitors are used to treat irritable bowel syndrome with constipation (IBS-C) and hyperphosphatemia in chronic kidney disease. NHE3 inhibitors work by blocking the sodium/hydrogen exchanger 3 (NHE3) protein in the intestines and kidneys, which helps to regulate sodium, phosphorus, and fluid balance in your body. These medications are available as oral pills. A main example is tenapanor (Ibsrela, Xphozah).

Prices for popular NHE3 Inhibitors medications
Viewing 2 of 2 medications
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Ibsrela

TENAPANOR treats irritable bowel syndrome (IBS) with constipation. It works by softening the stool, making it easier to have a bowel movement.
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Xphozah

TENAPANOR treats high phosphorus levels in people with kidney disease. It works by lowering the amount of phosphorus your body absorbs from food.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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