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Xphozah Coupon - Xphozah 30mg tablet

Xphozah

tenapanor
Used for Hyperphosphatemia
Used for Hyperphosphatemia

Xphozah (tenapanor) is a prescription medication that's used to lower blood phosphate levels in adults with chronic kidney disease (CKD) on dialysis. It's the first and only FDA-approved phosphate absorption inhibitor of its kind; it prevents your gut from absorbing phosphate into your blood. Xphozah (tenapanor) is a tablet that's taken by mouth twice a day, before breakfast and dinner. A common side effect is diarrhea, but it usually goes away as you continue treatment.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on January 30, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Xphozah (tenapanor)?

What is Xphozah (tenapanor) used for?

  • Add-on treatment for lowering blood phosphorus levels in adults with chronic kidney disease (CKD) on dialysis who haven't responded well to or can't take phosphate binders

How Xphozah (tenapanor) works

Xphozah (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor. It works by blocking NHE3, which is a protein in your gut that regulates the amount of fluids and electrolytes (like phosphorous) in your body.

By blocking NHE3, the medication prevents some of the phosphorus from food from being absorbed into your body. This helps lower your blood phosphate levels, which is important for protecting your kidneys and bones from damage due to phosphate buildup in CKD.

Are you looking for information on Ibsrela (tenapanor) instead?

Drug Facts

Common BrandsXphozah
Drug ClassNHE3 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Xphozah (tenapanor)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (43-53%)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe diarrhea

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Xphozah (tenapanor)

thumbs-up

Pros

Might work well for people who didn’t see benefits with other medications that help lower blood phosphate levels

Can take during pregnancy

thumbs-down

Cons

Taken before breakfast and dinner every day

High risk of diarrhea

Not safe for use in children under 6 years old and hasn't been well-studied in children of all ages

pharmacist-tips

Pharmacist tips for Xphozah (tenapanor)

pharmacist

  • Take Xphozah (tenapanor) 5 to 10 minutes before breakfast and dinner. This can help the medication work best for you.

    • Try to take Xphozah (tenapanor) around the same times every day. If you accidentally forgot to take the medication, then skip the missed dose and take the medication at your next regularly scheduled dose.

      • On your dialysis days, take Xphozah (tenapanor) right before the next meal you have after your dialysis session. Xphozah (tenapanor) can commonly cause diarrhea, which can lead to dehydration (low fluids in the body) and low levels of sodium. This is especially dangerous during your dialysis session.

        • Avoid taking Xphozah (tenapanor) within 3 hours of sodium polystyrene sulfonate (SPS), a medication that helps lower blood potassium levels. Sodium polystyrene sulfonate (SPS) might cause Xphozah (tenapanor) to work less well in your body.

          • Don't take Xphozah (tenapanor) with stool softeners or laxatives. Xphozah (tenapanor) can sometimes cause diarrhea, which can worsen with these medications.

            • Let your provider or pharmacist know what medications you're taking or planning to take, including over-the-counter products and supplements. Your providers can check for drug interactions with Xphozah (tenapanor) and make sure all your medications are safe to take together.

              faqs

              Frequently asked questions about Xphozah (tenapanor)

              Does Xphozah (tenapanor) cause diarrhea?
              Yes, Xphozah (tenapanor) can commonly cause diarrhea. In clinical studies, about half of the people who took this medication had diarrhea. Most cases were mild to moderate. Diarrhea typically happens soon after you start treatment, but it should get better as you continue to take Xphozah (tenapanor). Make sure to drink plenty of fluids to stay hydrated. Talk to your provider if you continue to have multiple watery bowel movements per day while you're taking Xphozah (tenapanor). Your provider might lower your dose or discuss with you about other ways to manage this side effect.
              What's the difference between Xphozah (tenapanor) and Renvela?
              Xphozah (tenapanor) and sevelamer carbonate (Renvela) are both medications that lower blood phosphate levels in people with CKD on dialysis, but they work differently. Xphozah (tenapanor) is a phosphate blocker. It works by blocking certain proteins in your gut from absorbing phosphate from food that you ate. On the other hand, sevelamer carbonate (Renvela) is a phosphate binder. It physically attaches to the phosphate from food so your body can't absorb it. In addition, Xphozah (tenapanor) is taken before breakfast and dinner. But sevelamer carbonate (Renvela) is taken with every meal you have so you might have to take it more often than Xphozah (tenapanor). Talk with your provider to see which medication is a better option for you.
              Can you take Xphozah (tenapanor) without food?
              You should take Xphozah (tenapanor) right before your morning and evening meals for the medication to work the best it can. Studies show that Xphozah (tenapanor) can lower your phosphate levels better if you take it 5 to 10 minutes before these meals. The medication works by blocking proteins in your gut from absorbing the phosphate that's in the food you just ate. Xphozah (tenapanor) won't work as well if you take it on an empty stomach because there's no phosphate from food to block.
              How well does Xphozah (tenapanor) work?
              Clinical studies showed that people who took Xphozah (tenapanor) had lower blood phosphate levels than people who took a placebo after 6 months. In addition, Xphozah (tenapanor) might work well if you haven't had improvement with phosphate binders. A 4-week study showed that adding Xphozah (tenapanor) to a phosphate binder dropped blood phosphate levels more than a phosphate binder alone. Your provider will order blood work to check your phosphate levels and see how well the medication is working for you. Discuss with your provider about your lab results and your Xphozah (tenapanor) treatment.
              Can you take Xphozah (tenapanor) without a phosphate binder?
              Depending on your situation, it might be possible for you to take Xphozah (tenapanor) without a phosphate binder. Xphozah (tenapanor) can help lower blood phosphate levels in adults with CKD on dialysis in two different situations. Some people need extra help lowering their phosphate levels even if they're already taking a phosphate binder, so adding Xphozah (tenapanor) to phosphate binder therapy can be beneficial. But for people who can't tolerate phosphate binders, taking Xphozah (tenapanor) alone is an option. Talk to your provider about whether you've already tried other medications to lower your blood phosphate levels. Your provider will help you decide on a treatment plan that works for you.
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              What are the risks and warnings for Xphozah (tenapanor)?

              Xphozah (tenapanor) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Diarrhea

              • Risk factors: People under 6 years of age | History of irritable bowel syndrome (IBS)

                People on dialysis who take Xphozah (tenapanor) commonly experience diarrhea as a side effect. Severe diarrhea can even lead to dehydration and low sodium levels, which can be dangerous.

                In clinical studies, more than half of the people who took Xphozah (tenapanor) had diarrhea. People typically reported diarrhea soon after they started taking the medication, but it can happen at any time during treatment. Most cases of diarrhea were mild to moderate and went away as treatment continued or after the dose was lowered.

                Let your provider know right away if you have diarrhea that doesn't improve after 2 days, severe belly pain, or bloody stool. Your provider might ask you to stop Xphozah (tenapanor).

                dosage

                Xphozah (tenapanor) dosage forms

                Typical dosing for Xphozah (tenapanor)

                The typical dose is 30 mg by mouth twice a day, before morning and evening meals.

                contraindications-icon

                Xphozah (tenapanor) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Xphozah (tenapanor) will not be safe for you to take.

                • Children under 6 years old because of the risk of diarrhea and serious dehydration

                • Blockage in the gut

                alternatives

                What are alternatives to Xphozah (tenapanor)?

                There are a number of medications that your doctor can prescribe in place of Xphozah (tenapanor). Compare a few possible alternatives below.
                Xphozah (tenapanor)
                Used for:

                • Add-on treatment for lowering blood phosphorus levels in adults with chronic kidney disease (CKD) on dialysis who haven't responded well to or can't take phosphate binders

                View Prices
                Sevelamer carbonate (Renvela)
                Used for:

                • High blood phosphate levels in people ages 6 years and older with chronic kidney disease (CKD) on dialysis

                $33.14 Lowest GoodRx priceView Prices
                Velphoro (sucroferric oxyhydroxide)
                Used for:

                • High blood phosphate levels in people with advanced kidney disease on dialysis

                $1559.64 Lowest GoodRx priceView Prices
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                Xphozah (tenapanor) images

                Red Oval T30 And Logo - XPHOZAH 30mg Tablet
                This medicine is Red, Oval Tablet Imprinted With "T30" And "Logo".Red Oval T30 And Logo - XPHOZAH 30mg Tablet

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                References

                Best studies we found

                American Kidney Fund. (2024). High phosphorus (hyperphosphatemia).

                Ardelyx, Inc. (2023). FDA approves Xphozah®, a first-in-class phosphate absorption inhibitor. Globe Newswire.

                Ardelyx, Inc. (2023). Xphozah 10 mg- tenapanor tablet, film coated; Xphozah 20 mg- tenapanor tablet, film coated; Xphozah 30 mg- tenapanor tablet, film coated [package insert]. DailyMed.

                View All References (5)

                Block, G. A., et al. (2021). Safety and efficacy of tenapanor for long-term serum phosphate control in maintenance dialysis: A 52-week randomized phase 3 trial (PHREEDOM). Kidney360.

                King, A. J., et al. (2018). Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Science Translational Medicine.

                National Kidney Foundation. (n.d.). Dialysis.

                Pergola, P. E., et al. (2021). A randomized trial of tenapanor and phosphate binders as a dual-mechanism treatment for hyperphosphatemia in patients on maintenance dialysis (AMPLIFY). Journal of the American Society of Nephrology.

                Shaman, A. M., et al. (2016). Hyperphosphatemia management in patients with chronic kidney disease. Saudi Pharmaceutical Journal.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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