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Compare Lomotil vs. Viberzi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lomotil (diphenoxylate/atropine) and Viberzi (eluxadoline) are both medications used to treat diarrhea, but they have some key differences. Lomotil is a combination of an opioid (diphenoxylate) and an anticholinergic (atropine), and it is used to treat general diarrhea. It is a Schedule V controlled substance and is available in both tablet and oral solution forms. Viberzi, on the other hand, is specifically used for irritable bowel syndrome with diarrhea (IBS-D) and is a Schedule IV controlled substance. It works by attaching to opioid receptors in the gut to reduce abdominal pain and diarrhea. Viberzi must be taken twice daily with food, while Lomotil is taken up to four times a day. Lomotil is available as a generic, making it potentially more affordable, whereas Viberzi does not have a generic form. Additionally, Viberzi cannot be used by people without a gallbladder or those who drink heavily due to the risk of pancreatitis, a serious side effect not associated with Lomotil.

  • Lomotil (diphenoxylate / atropine)
    Viberzi (eluxadoline)
  • Lomotil (diphenoxylate / atropine)
    Viberzi (eluxadoline)

  • Summary of Lomotil vs. Viberzi

    Summary for Opioid / Anticholinergic
    Prescription only

    Lomotil (diphenoxylate / atropine) is an antidiarrheal combination medication containing diphenoxylate (an opioid) and atropine (an anticholinergic). It's used to treat diarrhea in people 13 years and older. You usually start by taking it 4 times a day until the diarrhea is under control, then switch to a lower dose. The medication is available in both brand-name and generic versions. Lomotil (diphenoxylate / atropine) is a controlled substance, so there might be specific requirements for getting it filled at the pharmacy. Side effects include sleepiness, dizziness, and nausea.

    Summary for Opioid receptor agonist/antagonist
    Prescription only

    Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It works on the opioid receptor to help ease symptoms such as stomach pain and diarrhea. You typically take a dose by mouth twice a day with food. Because of its potential for misuse and dependence, it’s considered a controlled substance. Common side effects include constipation, nausea, and stomach pain.

  • Indications of Lomotil vs. Viberzi

    Indications for
    •Add-on therapy for diarrhea for people 13 years and older
    Indications for
    •Irritable bowel syndrome with diarrhea (IBS-D) in adults

  • Pros and Cons of Lomotil vs. Viberzi

    Pros and Const for Opioid / Anticholinergic
    Pros
    •Dose can be adjusted based on your symptoms
    •Can be taken with or without food
    •Comes as a tablet and solution that you take by mouth
    •Available as a lower-cost generic
    Cons
    •Need to take multiple times a day in the beginning
    •Can't be used if diarrhea is caused by certain bacteria
    •Can cause serious side effects in young children
    •Potentially interact with a lot of medications
    Pros and Const for Opioid receptor agonist/antagonist
    Pros
    •Tablet that's taken by mouth
    •Typically works within a week
    •Approved for males and females with IBS-D
    Cons
    •Must be taken twice a day with food
    •Is a controlled substance
    •Risk of pancreatitis, inflammation of the pancreas

  • Common Side Effects of Lomotil vs. Viberzi

    Common Side Effects for
    •Sleepiness
    •Dizziness
    •Nausea
    •Vomiting
    •Headache
    •Loss of appetite
    Common Side Effects for
    •Constipation (8%)
    •Nausea (7%)
    •Stomach pain (7%)

  • Warnings of Lomotil vs. Viberzi

    Common Side Effects for
    •Breathing problems
    •Sleepiness and dizziness
    •Dehydration
    •Serious bowel problems
    Common Side Effects for
    •Pancreatitis
    •Bile duct muscle spasm
    •Allergic reactions
    •Constipation

  • Prices with our coupons for Lomotil vs. Viberzi

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