Key takeaways
Cholestyramine (Prevalite) and bismuth subsalicylate (Pepto-Bismol) are used for different health issues and belong to different medication classes. Cholestyramine is a bile acid sequestrant that helps lower cholesterol and treats itching caused by bile duct blockage. It is available only by prescription and comes in a powder form that you mix with liquids. On the other hand, bismuth subsalicylate is an over-the-counter antidiarrheal that treats diarrhea and upset stomach symptoms like gas and nausea. It comes in various forms, including chewable tablets and liquid. While cholestyramine can cause constipation and requires careful timing with other medications, bismuth subsalicylate can cause dark-colored stools and tongue and should not be used for more than two days. Additionally, bismuth subsalicylate is not safe for children under the age of 12, due to the risk of Reye's syndrome, whereas cholestyramine has no such age restriction.
