Key takeaways
Omeprazole (Prilosec) and bismuth subsalicylate (Pepto-Bismol) are both used to treat stomach-related issues, but they work in different ways and treat different conditions. Omeprazole is a proton pump inhibitor (PPI) that reduces stomach acid and is used for conditions like GERD, stomach ulcers, and heartburn. It is available both over-the-counter and by prescription. Bismuth subsalicylate, on the other hand, is an antidiarrheal medication that treats diarrhea and symptoms of an upset stomach, such as nausea and gas. It is only available over-the-counter. Omeprazole is typically taken once daily before breakfast, while bismuth subsalicylate can be taken every 30 minutes to an hour as needed. Omeprazole is not recommended for long-term use due to potential serious side effects, whereas bismuth subsalicylate should not be taken for more than two days. Additionally, bismuth subsalicylate can cause dark-colored stools and tongue, while omeprazole may cause headaches and stomach pain.
