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Clopidogrel Coupon - Clopidogrel 75mg tablet

clopidogrel

Generic Plavix
Used for Heart Attack, Stroke Risk Reduction, Peripheral Artery Disease
Used for Heart Attack, Stroke Risk Reduction, Peripheral Artery Disease

Clopidogrel (also known by its brand name, Plavix) is a medication that's used to prevent heart attack and stroke in certain people who are at higher risk for those events. It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on July 20, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
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What is Clopidogrel (Plavix)?

What is Clopidogrel (Plavix) used for?

For people with a history of a heart attack, stroke, or peripheral artery disease:

How Clopidogrel (Plavix) works

Clopidogrel (Plavix) is a P2Y12 inhibitor, which is a type of antiplatelet medication. It works by preventing platelets from clumping up together and forming blood clots in your heart or brain. This lowers your risk for a heart attack or stroke.

When does Clopidogrel (Plavix) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsPlavix
Drug ClassP2Y12 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

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basics-icon

What are the side effects of Clopidogrel (Plavix)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Minor bleeding (5%)
  • Major bleeding (4%)

Other Side Effects

  • Bruising
  • Itchiness
  • Nosebleeds
  • Stomach and intestinal ulcers
  • Headache
  • Changes in taste
  • Confusion

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe bleeding: feeling faint, lightheaded, dizziness, vomiting blood, bloody or dark-colored stools, severe stomach pain or discomfort
  • Thrombotic thrombocytopenic purpura (a blood clotting problem): headache, confusion, dizziness, fever, bleeding in your skin, bruising, tiredness, stomach pain, blood in urine, making less urine
When do Clopidogrel (Plavix) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Rash or itching
Risk for bruising
Risk for minor bleeds (e.g., nosebleed)
Risk for major bleeds
Thrombotic thrombocytopenic purpura (TTP)
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Clopidogrel (Plavix) side effects

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7 Plavix Side Effects and How to Manage Them

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The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Collection of blood under the skin

deep, dark purple bruise

itching, pain, redness, or swelling

Less common

Bloody nose

bloody, black, or tarry stools

vomiting of blood or material that looks like coffee grounds

Rare

Bleeding in the eye

confusion

headache, sudden, severe, and continuing

nausea and vomiting

Incidence not known

Anxiety

blistering, peeling, loosening of the skin

bloating

blurred vision

burning upper stomach pain

change in mental status

chest pain or tightness

cold sweats

coma

constipation

cool, pale skin

cough or hoarseness

dark or bloody urine

difficulty in breathing or swallowing

difficulty speaking

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast heartbeat

feeling of discomfort

fever with or without chills

general feeling of tiredness or weakness

hives, itching, skin rash

increased hunger

indigestion

inflammation of the joints

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs

light-colored stools

loss of appetite

lower back or side pain

muscle aches

nervousness

nightmares

noisy breathing

painful or difficult urination

pains in the side, possibly radiating to the back

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash with flat lesions or small raised lesions on the skin

rectal bleeding

red irritated eyes

red skin lesions, often with a purple center

reddening of the skin, especially around the ears

seizures

shakiness

skin blisters

slurred speech

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stomach cramps, tenderness, or pain

sweating

swelling of the eyes, face, or inside of the nose

swelling or inflammation of the mouth

swollen or painful glands

trouble breathing

unusual bleeding or bruising

watery or bloody diarrhea

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Change in taste bad unusual or unpleasant (after) taste

difficulty in moving

loss of sense of taste

muscle aches, cramps, or stiffness

redness or swollen joints

seeing, hearing, or feeling things that are not there

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Clopidogrel (Plavix)

thumbs-up

Pros

Works well to lower your risk of having a heart attack or stroke

Only taken once a day by mouth

Available as a lower-cost, generic form

thumbs-down

Cons

Can cause major bleeding or bruising

Has many interactions with other medications

Might not work as well for people with East Asian descent

pharmacist-tips

Pharmacist tips for Clopidogrel (Plavix)

pharmacist

  • Take clopidogrel (Plavix) with or without food. But avoid grapefruit or grapefruit juice because they interact with clopidogrel (Plavix) causing the medication to not work as well.

    • Clopidogrel (Plavix) can make you bleed more easily. Stop taking the medication and get medical help right away if you feel lightheaded, dizzy, are vomiting or coughing up blood, or have blood in your stool. These are signs of bleeding that might be happening inside your body.

      • Get medical help right away if you fall and hit your head while taking clopidogrel (Plavix). Your provider will want to check to make sure you don't have any brain bleeds.

        • Clopidogrel (Plavix) interacts with several commonly used medications. Some medications need to be avoided while others might need their dose adjusted or you need closer monitoring. Tell your provider and pharmacist about all of the medications and supplements you're taking before and during treatment with clopidogrel (Plavix) to make sure the combination is as safe for you as possible.

          • Don't stop taking clopidogrel (Plavix) unless your provider specifically tells you it's safe to do so. This can cause blood clots to form in your body, which can be severe and life-threatening. If you're wanting to stop clopidogrel (Plavix) or switch to another blood thinner, ask your provider how to do so safely.

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            faqs

            Frequently asked questions about Clopidogrel (Plavix)

            Is clopidogrel (Plavix) a blood thinner?
            Yes, clopidogrel (Plavix) is an antiplatelet medication. It stops platelets from clumping up together and forming blood clots. Because of this, blood thinners like clopidogrel (Plavix) raise your risk for bleeding and bruising. Make sure to contact your provider if you notice unusual bleeding (e.g., bloody urine or stool, coughing up or vomiting blood) or having trouble stopping a bleed.
            What should you not take with clopidogrel (Plavix)?
            Clopidogrel (Plavix) interacts with several medications. Don't take omeprazole (Prilosec) or esomeprazole (Nexium) with clopidogrel (Plavix) because they can lower how well clopidogrel (Plavix) works. You also should be careful when taking NSAIDs (e.g., ibuprofen (Advil), naproxen (Aleve)) because these can raise your risk of bleeding. Also, there are other medications that raise your risk of bleeding, such as certain antidepressants and anticoagulants). Make sure to tell your provider about all medications and supplements you're taking. They can help check for interactions and make sure your medications are safe to take with clopidogrel (Plavix).
            What foods should I avoid with clopidogrel (Plavix)?
            Avoid grapefruit or grapefruit juice while taking clopidogrel (Plavix) because it can make clopidogrel (Plavix) not work as well, which raises your risk for a heart attack or stroke. Other than that, there aren't any other specific foods that affect clopidogrel (Plavix). In fact, foods like leafy green vegetables that are typically limited with warfarin (Coumadin) (another common blood thinner), can still be eaten while taking clopidogrel (Plavix).
            Can you still have a stroke or heart attack when taking clopidogrel (Plavix)?
            Yes. Clopidogrel (Plavix) works well to lower your risk of having a stroke or heart attack, but it's still possible to have a stroke or heart attack even while you're taking this medication. This is because your risk for these events depends on several things, like your medical conditions, other medications you're taking, and your lifestyle. It's important to do what you can to keep your risk as low as possible, such as eating healthy and regular exercise.
            When should I stop clopidogrel (Plavix) before surgery?
            You need to stop clopidogrel (Plavix) 5 days before any surgery or procedure with a high risk of bleeding. But it's important to discuss with your provider if you should stop taking clopidogrel (Plavix). This is because not all surgeries or procedures require you to stop the medication.
            How long should you take clopidogrel (Plavix)?
            It varies. In general, clopidogrel (Plavix) is initially taken for a month to at least 1 year, depending on the reason you're taking the medication. But, the length of time you need clopidogrel (Plavix) will depend on your specific situation and risk factors for bleeding or clotting. Some people need to take it for just a few months while others might need it for the rest of their lives. Don't stop taking clopidogrel (Plavix) unless your provider specifically told you to do so.
            Why are aspirin and clopidogrel (Plavix) used together?
            While both clopidogrel (Plavix) and aspirin are antiplatelets medications, they work slightly differently from each other. There are many studies to see if using either medication alone or both together works better to prevent heart attacks and strokes. In general, research shows using both medications in people with heart problems works better, but also raises the risk of bleeding. Also, according to the 2021 stroke prevention guidelines, only people with certain severe types of stroke should use both aspirin and clopidogrel (Plavix). Your provider might suggest using either one or both medications based on your specific situation and needs.
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            What are the risks and warnings for Clopidogrel (Plavix)?

            Clopidogrel (Plavix) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Clopidogrel (Plavix) not working as well

            • Risk factors: Taking omeprazole (Prilosec) or esomeprazole (Nexium) | Having certain genes that make clopidogrel (Plavix) work less


              Certain people with a specific gene might not respond as well to clopidogrel (Plavix) because of how their bodies break down the medication. Don't start any new medications, vitamins, or supplements without first talking to your healthcare provider or pharmacist, since they could interfere with how clopidogrel (Plavix) works.

              risk-warning

              Bleeding

              • Risk factors: Taking other medications that raise the risk for bleeding

                Taking clopidogrel (Plavix) can raise your risk for bleeding. Also, this medication might make it take longer than usual for bleeding to stop. You might also notice that you get bruises more easily or have more bleeding when you get a cut or nosebleed. Your risk is higher if you're also taking other medications that can cause bleeding. Tell your provider right away if you notice any abnormal bleeding, see any blood in your stool or urine, or feel more dizzy. Get medical help right away if you have a fall, head injury, or other kinds of physical injury since you might have bleeding inside your body. And contact your provider right away if you have dark or tarry stool or bleeds that are difficult to stop.

                risk-warning

                Risk of heart attack or stroke if stopped suddenly

                • Risk factors: Stopping clopidogrel (Plavix) suddenly | Recent heart attack or stent

                  Don't stop taking clopidogrel (Plavix) unless your provider specifically tells you it's safe to do so. Stopping the medication too early can cause a heart attack or stroke. If you're wanting to stop clopidogrel (Plavix), contact your provider so they can create a safe plan for you.

                  risk-warning

                  Thrombotic thrombocytopenic purpura (TTP)

                  Clopidogrel (Plavix) can cause a rare, life-threatening blood condition called thrombotic thrombocytopenic purpura (TTP) where blood clots form in small blood vessels. Sometimes it can happen within the first 2 weeks of starting clopidogrel (Plavix). Get medical help right away if you have fever, unusual bleeding, easy bruising, weakness, dizziness, tiredness, or trouble breathing.

                  risk-warning

                  Allergic reaction

                  • Risk factors: Allergy to prasugrel (Effient) or ticagrelor (Brilinta)

                    Allergic reactions to clopidogrel (Plavix) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis. If you are allergic to prasugrel (Effient) or ticagrelor (Brilinta), you might also be allergic to clopidogrel (Plavix). Stop taking clopidogrel (Plavix) and call your doctor if you notice a rash or hives after taking this medication. Get medical help right away if you experience swelling in your face, throat, or tongue.

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                    dosage

                    Clopidogrel (Plavix) dosage forms

                    The average cost for 30 tablets of 75mg of Clopidogrel (Plavix) is $4.50 with a free GoodRx coupon. This is 93.19% off the average retail price of $66.09.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    75mg30 tablets$4.50$0.15
                    300mg2 tablets$22.70$11.35

                    Typical dosing for Clopidogrel (Plavix)

                    The typical dose is 75 mg by mouth once a day.

                    For people who are in the hospital right after a heart attack, a single 300-mg loading dose is given first.

                    More on Clopidogrel (Plavix) dosage forms

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                    interactions

                    Interactions between Clopidogrel (Plavix) and other drugs

                    Clopidogrel (Plavix) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Clopidogrel (Plavix). Please note that only the generic name of each medication is listed below.

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                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    • Defibrotide

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                    How much does Clopidogrel (Plavix) cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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                    contraindications-icon

                    Clopidogrel (Plavix) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Clopidogrel (Plavix) will not be safe for you to take.

                    • Active bleeding

                    alternatives

                    What are alternatives to Clopidogrel (Plavix)?

                    There are a number of medications that your doctor can prescribe in place of Clopidogrel (Plavix). Compare a few possible alternatives below.
                    Clopidogrel (Plavix)
                    Used for:

                    For people with a history of a heart attack, stroke, or peripheral artery disease:

                    $4.50 Lowest GoodRx priceView Prices
                    Brilinta (ticagrelor)
                    Used for:
                    $446.40 Lowest GoodRx priceView Prices
                    Prasugrel (Effient)
                    Used for:

                    • Prevention of blood clot problems in people who received a stent after a heart attack

                    $21.99 Lowest GoodRx priceView Prices
                    latest news

                    What is the latest news about Clopidogrel (Plavix)?

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                    7 Plavix Side Effects and How to Manage Them

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                    Plavix Dosages for Adults: Your GoodRx Guide

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                    Plavix vs. Eliquis: 7 Things to Know When Comparing These Blood Thinners

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                    Brilinta and Plavix are antiplatelet medications. They work in a similar way, but have different dosing and drug interactions that could make one a better option for you.

                    Brilinta vs. Plavix to Prevent Blood Clots: 7 Factors to Consider

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                    Clopidogrel (Plavix) interacts with PPIs, NSAIDs like Advil, and anticoagulants like Eliquis. See more common clopidogrel interactions (medications and food), plus ways to avoid them.

                    9 Clopidogrel Interactions You Should Know About

                    Clopidogrel (Plavix) interacts with PPIs, NSAIDs like Advil, and anticoagulants like Eliquis. See more common clopidogrel interactions (medications and food), plus ways to avoid them.
                    Plavix (clopidogrel) is taken with aspirin to prevent developing blood clots after a heart attack, a stent placement, or other heart-related event. Learn about Plavix side effects, dosage, and how long to take this medication for.

                    How Long Will I Need to Take Plavix (Clopidogrel) After a Heart Attack?

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                    Vitamin deficiencies, certain health conditions, and even side effects of some medications can lead to a higher risk of easy bruising and bleeding. Learn more about possible causes here.

                    What Causes Easy Bruising? 6 Medications to Watch For

                    Vitamin deficiencies, certain health conditions, and even side effects of some medications can lead to a higher risk of easy bruising and bleeding. Learn more about possible causes here.
                    images

                    Clopidogrel (Plavix) images

                    Pink Oblong Tv And 7314 - Clopidogrel 75mg Tablet
                    This medicine is Pink, Oblong Tablet Imprinted With "Tv" And "7314".Pink Oblong Tv And 7314 - Clopidogrel 75mg Tablet
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                    This medicine is Pink, Round Tablet Imprinted With "Mc5".Pink Round Mc5 - Clopidogrel 75mg Tablet
                    Pink Round Sg 124 - Clopidogrel 75mg Tablet
                    This medicine is Pink, Round Tablet Imprinted With "Sg 124".Pink Round Sg 124 - Clopidogrel 75mg Tablet

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                    References

                    Best studies we found

                    American Red Cross. (n.d.). Platelets and thrombocytopenia.

                    Cheema, A.N., et al. (2011). Characterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation. Journal of the American College of Cardiology.

                    Kleindorfer, D. O., et al. (2021). 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack A guideline from the American Heart Association/American Stroke Association. Stroke.

                    View All References (7)

                    National Cancer Institute Dictionary of Cancer Terms. (n.d.). Platelet.

                    Paciaroni, M., et al. (2019). Benefits and risks of clopidogrel vs. aspirin monotherapy after recent ischemic stroke: A systematic review and meta-analysis. Cardiovascular Therapeutics.

                    Pereira, N. L., et al. (2019). Clopidogrel pharmacogenetics: State-of-the-art review and the TAILOR-PCI Study. Circulation: Cardiovascular Interventions.

                    Squizzato, A., et al. (2017). Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events. The Cochrane Database of Systematic Reviews.

                    Stanley, M., et al. (2023). Thrombotic thrombocytopenic purpura. StatPearls.

                    Torrent Pharmaceuticals Limited. (2023). CLOPIDOGREL BISULFATE tablet [package insert]. DailyMed.

                    Zakarija, A., et al. (2004). Clopidogrel-associated TTP: An update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration. Stroke.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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