Key takeaways
Ticagrelor (Brilinta) and clopidogrel (Plavix) are both antiplatelet medications used to lower the risk of heart attack or stroke. They belong to the same class of medications called P2Y12 inhibitors. However, they have some differences. Ticagrelor is taken twice a day, while clopidogrel is taken once a day. Ticagrelor is available only as a brand-name medication, whereas clopidogrel is available as a generic, which can be more affordable. Common side effects of ticagrelor include shortness of breath and nausea, while clopidogrel can cause headaches and changes in taste. Both medications can increase the risk of bleeding and interact with NSAIDs. Additionally, ticagrelor should not be taken with grapefruit juice, while clopidogrel should be avoided with proton pump inhibitors (PPIs).
