Key takeaways
Heparin and Xarelto (rivaroxaban) are both anticoagulants, or blood thinners, used to treat and prevent blood clots. They are similar in that they help manage conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE). However, they differ in several ways. Heparin is an injectable medication, while Xarelto comes as an oral medication. Heparin is often used in hospital settings and requires regular blood tests to monitor its effects, whereas Xarelto does not require frequent blood tests. Both medications are available as a lower-cost generic. Because both medications are blood thinners, they can increase the risk of bleeding. Heparin has an antidote called protamine, while Xarelto's reversal medication is called Andexxa.
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