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Lodine vs. Plavix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Etodolac (Lodine) and Clopidogrel (Plavix) are both prescription medications with several differences between them. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis. It works by blocking proteins that cause inflammation. Clopidogrel, on the other hand, is a blood thinner helps prevent heart attack and stroke by stopping platelets from clumping together to form blood clots. While etodolac is taken multiple times a day, clopidogrel is usually taken once a day. Etodolac can cause side effects like stomach pain and indigestion, whereas clopidogrel can lead to bleeding and bruising. Additionally, you should avoid alcohol with etodolac due to the increased risk of stomach bleeding, while grapefruit should be avoided with clopidogrel as it can interfere with the medication's effectiveness.

Etodolac

 

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Clopidogrel

(Plavix)

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Summary for Lodine

Prescription only

Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

Indications for Lodine

Pros and Cons for Lodine

Pros

  • Works well to treat pain and inflammation
  • Extended-release tablets can be used for children as young as 6 years old
  • Available as a lower-cost generic

Cons

  • Only available as pills that can't be split, open, or crushed
  • Not safe to take after 20 weeks of pregnancy
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems

Common Side Effects for Lodine

The following side effects were reported in 1% to 10% of people who took etodolac:

Warnings for Lodine

  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions and skin reactions
  • Not safe to take while pregnant
  • Risk for bleeding

Summary for Plavix

Prescription only

Clopidogrel (Plavix) is a prescription antiplatelet medication that helps lower your risk of heart attack or stroke. It works by stopping platelets in your blood from sticking together and forming clots. You take it as a tablet by mouth once a day, and it might be used alone or with aspirin in some situations. Since it's a blood thinner, the most common side effect is bleeding.

Indications for Plavix

Pros and Cons for Plavix

Pros

  • Good choice for lowering the risk of heart attack or stroke
  • Tablet that's taken once a day by mouth
  • Can be taken with or without food

Cons

  • Can cause major bleeding or bruising
  • Has many interactions with other medications
  • Might not work as well for people with East Asian descent

Common Side Effects for Plavix

  • Minor bleeding (5%)
  • Major bleeding (4%)

Warnings for Plavix

  • Clopidogrel (Plavix) not working as well
  • Bleeding
  • Risk of heart attack or stroke if stopped suddenly
  • Blood clotting condition
  • Allergic reaction

Prices with our coupons for Lodine vs. Plavix

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Etodolac60 tablets / 400mg
$25.84$78.73
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Clopidogrel30 tablets / 75mg
$10.79$16.90
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