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Compare Lodine vs. Plavix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Etodolac (Lodine) and Clopidogrel (Plavix) are both prescription medications with several differences between them. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis. It works by blocking proteins that cause inflammation. Clopidogrel, on the other hand, is a blood thinner helps prevent heart attack and stroke by stopping platelets from clumping together to form blood clots. While etodolac is taken multiple times a day, clopidogrel is usually taken once a day. Etodolac can cause side effects like stomach pain and indigestion, whereas clopidogrel can lead to bleeding and bruising. Additionally, you should avoid alcohol with etodolac due to the increased risk of stomach bleeding, while grapefruit should be avoided with clopidogrel as it can interfere with the medication's effectiveness.

  • Etodolac
    Clopidogrel (Plavix)
  • Etodolac
    Clopidogrel (Plavix)

  • Summary of Lodine vs. Plavix

    Summary for NSAID
    Prescription only

    Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

    Summary for P2Y12 inhibitor
    Prescription only

    Clopidogrel (also known by its brand name, Plavix) is a medication that's used to prevent heart attack and stroke in certain people who are at higher risk for those events. It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).

  • Indications of Lodine vs. Plavix

    Indications for
    •Osteoarthritis (OA)
    •Rheumatoid arthritis (RA)
    •Juvenile idiopathic arthritis - extended-release only
    •Short-term pain - immediate-release only
    Indications for

    For people with a history of a heart attack, stroke, or peripheral artery disease:

    •Heart attack prevention
    •Stroke prevention

  • Pros and Cons of Lodine vs. Plavix

    Pros and Const for NSAID
    Pros
    •Works well to treat pain and inflammation
    •Extended-release tablets can be used for children as young as 6 years old
    •Available as a lower-cost generic
    Cons
    •Only available as pills that can't be split, open, or crushed
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
    Pros and Const for P2Y12 inhibitor
    Pros
    •Works well to lower your risk of having a heart attack or stroke
    •Only taken once a day by mouth
    •Available as a lower-cost, generic form
    Cons
    •Can cause major bleeding or bruising
    •Has many interactions with other medications
    •Might not work as well for people with East Asian descent

  • Common Side Effects of Lodine vs. Plavix

    Common Side Effects for

    The following side effects were reported in 1% to 10% of people who took etodolac:

    •Stomach pain
    •Indigestion or heartburn
    •Nausea
    •Vomiting
    •Constipation
    •Diarrhea
    •Passing gas
    •Stomach ulcer
    •Stomach bleeding
    •Swelling
    •Headache
    •Ringing in the ears
    •Itching
    •Rash
    •Anemia (low red blood cell count)
    •Elevated liver enzymes
    Common Side Effects for
    •Minor bleeding (5%)
    •Major bleeding (4%)

  • Warnings of Lodine vs. Plavix

    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions and skin reactions
    •Not safe to take while pregnant
    •Risk for bleeding
    Common Side Effects for
    •Clopidogrel (Plavix) not working as well
    •Bleeding
    •Risk of heart attack or stroke if stopped suddenly
    •Thrombotic thrombocytopenic purpura (TTP)
    •Allergic reaction

  • Prices with our coupons for Lodine vs. Plavix

    Learn more about Etodolac
    Learn more about Clopidogrel

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