Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Clopidogrel (Plavix) and warfarin (Coumadin) are both blood thinners, but they work differently and are used for different conditions. Clopidogrel is a P2Y12 inhibitor that prevents platelets from clumping together, which helps lower the risk of heart attacks and strokes. It's taken once a day and is available in a generic form. Warfarin, on the other hand, is a vitamin K antagonist that prevents blood clots by blocking vitamin K. It's used to treat and prevent blood clots in conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE). Warfarin also requires regular blood tests to monitor its effect, and its dose is adjusted based on these tests. Unlike clopidogrel, warfarin interacts with many foods and medications, and it has an antidote in case of emergency. Both medications can cause serious bleeding, but warfarin has additional risks like skin tissue death and is not safe during pregnancy.
Clopidogrel (Plavix)
Warfarin (Coumadin)
Clopidogrel (Plavix)
Warfarin (Coumadin)
Summary of Plavix vs. Coumadin
Summary for P2Y12 inhibitor
Prescription only
Clopidogrel (also known by its brand name, Plavix) is a medication that's used to prevent heart attack and stroke in certain people who are at higher risk for those events. It comes as a tablet taken by mouth once per day and is also available as a generic medication. Since it's a blood thinner, possible side effects include bleeding and bruising, especially if you take medications that interact with clopidogrel (Plavix) like certain antidepressants, anticoagulants, or non-steroidal anti-inflammatory drugs (NSAIDs).