Key takeaways
Clopidogrel (Plavix) and apixaban (Eliquis) are both medications used to lower the risk of blood clots, which can lead to heart attacks or strokes. However, they belong to different medication classes. Clopidogrel is a P2Y12 inhibitor, a type of antiplatelet medication, while apixaban is a direct-acting oral anticoagulant (DOAC). Clopidogrel is typically taken once a day, whereas apixaban is usually taken twice daily. Clopidogrel is available as a lower-cost generic, while apixaban is only available as a brand-name medication. Both medications can cause bleeding or bruising as common side effects. Clopidogrel interacts with medications like omeprazole, and both medications interact with other blood thinners and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin). Always talk to your healthcare professional about any medications you are taking to avoid interactions.
