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Compare Savaysa vs. Eliquis

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Savaysa (edoxaban) and Eliquis (apixaban) are both blood thinners used to prevent blood clots and strokes, but they have some differences. Savaysa is taken once daily, while Eliquis is taken twice daily. Savaysa does not have a generic version available, making it potentially more expensive, whereas Eliquis has a generic version approved but may not available until 2026. Savaysa isn’t recommended for people whose kidneys work too fast or too slow. Eliquis might be a better option for those with certain kidney problems. Eliquis can be used to prevent blood clots after hip or knee replacement surgery, but Savaysa isn’t used for this. Both medications can cause bleeding, but Eliquis has an antidote, while Savaysa doesn’t.

  • Savaysa (edoxaban)
    Eliquis (apixaban)
  • Savaysa (edoxaban)
    Eliquis (apixaban)

  • Summary of Savaysa vs. Eliquis

    Summary for Anticoagulant
    Prescription only

    Savaysa, the brand name for edoxaban, is an anticoagulant (blood thinner). It’s used to help prevent blood clots and strokes in certain people with atrial fibrillation. This medication can also treat blood clots. The dose is typically one 60 mg tablet by mouth once daily, but it might be lower if you have kidney problems. Since it’s a blood thinner medication, Savaysa (edoxaban) can raise your chance of bleeding as a side effect. As of early 2025, there's no FDA-approved generic version available yet.

    Summary for Direct-acting oral anticoagulant (DOAC)
    Prescription only

    Eliquis (apixaban) is an anticoagulant (blood thinner) used to prevent and treat blood clots. It can lower the risk of serious conditions like stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). The medication comes as a tablet or liquid and is taken by mouth twice a day. Common side effects include bleeding and bruising. Although generic versions have been approved by the FDA, they might not be available until 2026.

  • Indications of Savaysa vs. Eliquis

    Indications for
    •Prevention of stroke and blood clots in people with nonvalvular atrial fibrillation (NVAF)
    •Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) after 5 to 10 days of therapy with an injectable blood thinner
    Indications for

    Adults:

    •Lower the risk of stroke or blood clots in people with atrial fibrillation (AFib) not caused by a heart valve problem
    •Treat blood clots in the legs (deep vein thrombosis (DVT)) or lungs (pulmonary embolism (PE))
    •Prevent DVT and PE after knee or hip replacement surgery
    •Lower the risk of DVT or PE coming back after treatment

    Children:

    •Treat blood clots and lower the risk of new clots in children from birth and older

  • Pros and Cons of Savaysa vs. Eliquis

    Pros and Const for Anticoagulant
    Pros
    •Oral medication that's only taken once a day
    •Can take with or without food and doesn't interact with any specific foods
    •Doesn't require frequent blood tests to check how well it’s working and how safe it is
    Cons
    •Not for people with nonvalvular atrial fibrillation (NVAF) whose kidneys work too well
    •Not recommended if you have artificial heart valves or certain problems with your heart valves
    •Doesn't have an antidote (an option to reverse serious bleeding)
    Pros and Const for Direct-acting oral anticoagulant (DOAC)
    Pros
    •No regular blood monitoring required
    •Can be taken with or without food
    •Approved for both children and adults
    Cons
    •Need to take it twice a day
    •Most common side effect is bleeding
    •Not easily reversible in life-threatening bleeds

  • Common Side Effects of Savaysa vs. Eliquis

    Common Side Effects for
    •Any type of bleeding
    Common Side Effects for

    Adults:

    •Any bleeding (up to 15%)

    Children:

    •Any bleeding (up to 36%)
    •Headache (16%)
    •Vomiting (14%)

  • Warnings of Savaysa vs. Eliquis

    Common Side Effects for
    •Less effective for people with atrial fibrillation whose kidneys work too well
    •Higher risk of blood clots or stroke when you stop the medication too soon
    •Bleeding risk
    •Risk of bleeding around the spinal cord after spinal procedures
    •Higher risk of clotting in people with triple-positive antiphospholipid syndrome
    Common Side Effects for
    •Higher risk of blood clots if stopped too early
    •Paralysis in the spine
    •Bleeding
    •Not recommended in people with prosthetic heart valves
    •Not recommended in people with antiphospholipid syndrome

  • Prices with our coupons for Savaysa vs. Eliquis

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