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Compare Xarelto vs. Savaysa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Xarelto (rivaroxaban) and Savaysa (edoxaban) are both blood thinners used to prevent blood clots and strokes, but they have some differences. Xarelto is a direct-acting oral anticoagulant (DOAC) that works by stopping factor Xa, a protein involved in blood clotting. It’s used for a variety of conditions, including atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). It can be taken once or twice a day depending on the condition being treated. Savaysa also stops factor Xa but is typically taken once a day and is mainly used for nonvalvular atrial fibrillation (NVAF) and major blood clots. Unlike Xarelto, Savaysa doesn’t have an antidote for serious bleeding, making it potentially riskier in emergencies. Both are only available as brand-name medications. Neither require frequent blood tests like warfarin, but Xarelto can be used in very young children, whereas Savaysa is not indicated for pediatric use.

  • Xarelto (rivaroxaban)
    Savaysa (edoxaban)
  • Xarelto (rivaroxaban)
    Savaysa (edoxaban)

  • Summary of Xarelto vs. Savaysa

    Summary for Direct-acting oral anticoagulant (DOAC)
    Prescription only

    Xarelto (rivaroxaban) is a prescription blood thinner used to prevent and treat blood clots. It can lower the risk of serious problems like stroke, deep vein thrombosis (DVT), or pulmonary embolism (PE). It's comes as a tablet or liquid and is taken by mouth. Your dose depends on why you're taking it, so it could be once or twice a day. The most common side effect is bleeding, which can sometimes be serious or life-threatening. Xarelto (rivaroxaban) is available as both a brand-name and a generic medication.

    Summary for Anticoagulant
    Prescription only

    Savaysa, the brand name for edoxaban, is an anticoagulant (blood thinner). It’s used to help prevent blood clots and strokes in certain people with atrial fibrillation. This medication can also treat blood clots. The dose is typically one 60 mg tablet by mouth once daily, but it might be lower if you have kidney problems. Since it’s a blood thinner medication, Savaysa (edoxaban) can raise your chance of bleeding as a side effect. As of early 2025, there's no FDA-approved generic version available yet.

  • Indications of Xarelto vs. Savaysa

    Indications for

    Adults:

    •Lower the risk of stroke and blood clots in people with atrial fibrillation (AFib) not caused by a heart valve problem
    •Treat blood clots in the legs (deep vein thrombosis (DVT)) or lungs (pulmonary embolism (PE))
    •Lower the risk of DVT or PE coming back after treatment
    •Prevent DVT and PE after knee or hip replacement surgery
    •Prevent blood clots in people in the hospital or recently released who are at high risk
    •Lower the risk of serious heart problems, like heart attack or stroke, in people with coronary artery disease (CAD), taken with aspirin
    •Lower the risk of blood clots and related problems in people with peripheral artery disease (PAD), taken with aspirin

    Children:

    •Treat blood clots and lower the risk of new clots in children from birth to under 18 years old
    •Prevent blood clots in children 2 years and older with congenital heart disease (CHD) after a Fontan procedure
    Indications for
    •Prevention of stroke and blood clots in people with nonvalvular atrial fibrillation (NVAF)
    •Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) after 5 to 10 days of therapy with an injectable blood thinner

  • Pros and Cons of Xarelto vs. Savaysa

    Pros and Const for Direct-acting oral anticoagulant (DOAC)
    Pros
    •No regular blood monitoring required
    •Available as a tablet or liquid that's taken by mouth
    •Approved for both children and adults
    Cons
    •Most common side effect is bleeding
    •Not easily reversible in life-threatening bleeds
    •Can interact with many medications
    Pros and Const for Anticoagulant
    Pros
    •Oral medication that's only taken once a day
    •Can take with or without food and doesn't interact with any specific foods
    •Doesn't require frequent blood tests to check how well it’s working and how safe it is
    Cons
    •Not for people with nonvalvular atrial fibrillation (NVAF) whose kidneys work too well
    •Not recommended if you have artificial heart valves or certain problems with your heart valves
    •Doesn't have an antidote (an option to reverse serious bleeding)

  • Common Side Effects of Xarelto vs. Savaysa

    Common Side Effects for

    Adults

    •Any bleeding (Up to 28%)

    Children

    •Any bleeding (36%)
    •Cough (16%)
    •Vomiting (14%)
    •Stomach virus (13%)
    •Rash (9%)
    Common Side Effects for
    •Any type of bleeding

  • Warnings of Xarelto vs. Savaysa

    Common Side Effects for
    •Higher risk of blood clots if stopped too early
    •Paralysis in the spine
    •Bleeding
    •Interactions with other medications
    •Risk of pregnancy-related bleeding
    •Not recommended in people with prosthetic heart valves
    •Not recommended in people with antiphospholipid syndrome
    Common Side Effects for
    •Less effective for people with atrial fibrillation whose kidneys work too well
    •Higher risk of blood clots or stroke when you stop the medication too soon
    •Bleeding risk
    •Risk of bleeding around the spinal cord after spinal procedures
    •Higher risk of clotting in people with triple-positive antiphospholipid syndrome

  • Prices with our coupons for Xarelto vs. Savaysa

    Learn more about Xarelto
    Learn more about Savaysa

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