Key takeaways
Xarelto (rivaroxaban) and Savaysa (edoxaban) are both blood thinners used to prevent blood clots and strokes, but they have some differences. Xarelto is a direct-acting oral anticoagulant (DOAC) that works by stopping factor Xa, a protein involved in blood clotting. It’s used for a variety of conditions, including atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). It can be taken once or twice a day depending on the condition being treated. Savaysa also stops factor Xa but is typically taken once a day and is mainly used for nonvalvular atrial fibrillation (NVAF) and major blood clots. Unlike Xarelto, Savaysa doesn’t have an antidote for serious bleeding, making it potentially riskier in emergencies. Both are only available as brand-name medications. Neither require frequent blood tests like warfarin, but Xarelto can be used in very young children, whereas Savaysa is not indicated for pediatric use.
