Compare Plavix vs. Xarelto

Plavix (clopidogrel) and Xarelto (rivaroxaban) are both blood thinners used to prevent clots, but they differ in how they’re used and how they work. Plavix, an antiplatelet medication, reduces the risk of heart attack and stroke in people with certain conditions by preventing platelets from clumping. It’s taken once daily. Xarelto, an anticoagulant, blocks a protein in the blood involved in the clotting process. It treats a broader range of conditions than Plavix, such as deep vein thrombosis and pulmonary embolism. It’s also often taken once daily. Plavix is available as a lower-cost generic, but Xarelto is a brand-only medication. Both medications can cause bleeding and bruising as common side effects. Serious bleeding may also occur, although it’s rare.