Compare Aspirin vs. Acetaminophen

Acetaminophen (Tylenol) and aspirin are both over-the-counter medications used to relieve pain and reduce fever, but they have some key differences. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever. Aspirin can also act as a blood thinner at lower doses (81 mg) to help prevent heart attacks and strokes. On the other hand, acetaminophen can help relieve pain and fever, but it doesn't reduce inflammation. Aspirin can cause stomach irritation including heartburn and stomach upset. It can't be used in children under 12 years old or in children 18 years or younger with the flu due to risk of Reye's syndrome. Side effects are less common with acetaminophen and it's generally safer for children. There's a possible risk of liver damage with acetaminophen, especially if taken with alcohol. Both medications are available in various forms, including tablets and suppositories, but they shouldn't be taken together without consulting a healthcare professional.