Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Ticlopidine and cilostazol are both medications used to prevent blood clots, but they have different uses and mechanisms. Ticlopidine is an antiplatelet medication that was used to lower the risk of stroke and prevent blood clotting after coronary stent implantation. It works by stopping platelets from sticking together. However, it is no longer available in the United States. On the other hand, cilostazol, available only by prescription, is a phosphodiesterase III inhibitor (PDE-3 inhibitor) used to ease pain and improve walking distance in people with intermittent claudication, a condition caused by poor blood flow in the legs. Cilostazol also prevents platelets from clumping and helps relax blood vessels. It must be taken on an empty stomach and is not safe for people with heart failure.
Ticlopidine
Cilostazol
Ticlopidine
Cilostazol
Summary of Ticlid vs. Pletal
Summary for Antiplatelet
Ticlopidine is used to lower the risk of stroke in certain people. It's also used to prevent blood clotting in people who have had coronary stent implantation. This medication was discontinued and is no longer available in the United States.
Summary for PDE-3 inhibitor
Prescription only
Cilostazol is a leg pain medication that helps adults with poor blood flow from a condition called intermittent claudication. It can help you walk longer distances with less pain or discomfort. Cilostazol belongs to a group of medications called PDE-3 inhibitors. It comes as a tablet that you take by mouth, usually twice a day on an empty stomach — at least 30 minutes before or 2 hours after breakfast and dinner. Common side effects include headache, diarrhea, and abnormal stools.