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Compare Lodine vs. Coumadin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Etodolac and Warfarin are both prescription medications, but they serve very different purposes. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation, particularly in conditions like osteoarthritis and rheumatoid arthritis. It works by blocking proteins that cause you to experience pain and inflammation. On the other hand, Warfarin is a blood thinner (anticoagulant) that prevents and treats blood clots by blocking vitamin K, which is necessary for blood clotting. Etodolac is taken multiple times a day for immediate-release or once daily for extended-release, while Warfarin is typically taken once daily with the dose adjusted based on blood tests. Etodolac can cause side effects like stomach pain and indigestion, whereas Warfarin can lead to serious bleeding and requires regular blood monitoring. Additionally, Etodolac is not safe to take with other NSAIDs, while Warfarin interacts with many foods and medications, requiring careful dietary and medication management.

  • Etodolac
    Warfarin (Coumadin)
  • Etodolac
    Warfarin (Coumadin)

  • Summary of Lodine vs. Coumadin

    Summary for NSAID
    Prescription only

    Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

    Summary for Vitamin K antagonist
    Prescription only

    Warfarin (Coumadin) is a blood thinner (anticoagulant). It's used to prevent and treat blood clots in adults and children with conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Warfarin (Coumadin) is taken by mouth, typically once daily. Your provider will adjust the dose based on your international normalized ratio (INR). Taking too much warfarin (Coumadin) can lead to side effects like bruising and serious bleeding. If needed, your provider can give you an antidote to reverse the effects of warfarin (Coumadin).

  • Indications of Lodine vs. Coumadin

    Indications for
    •Osteoarthritis (OA)
    •Rheumatoid arthritis (RA)
    •Juvenile idiopathic arthritis - extended-release only
    •Short-term pain - immediate-release only
    Indications for
    •Prevention and treatment blood clots in the veins
    •Prevention and treatment blood clots linked to atrial fibrillation (AFib) or heart valve replacement
    •Prevention of more blood clots and to lower risk of death after a heart attack

  • Pros and Cons of Lodine vs. Coumadin

    Pros and Const for NSAID
    Pros
    •Works well to treat pain and inflammation
    •Extended-release tablets can be used for children as young as 6 years old
    •Available as a lower-cost generic
    Cons
    •Only available as pills that can't be split, open, or crushed
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
    Pros and Const for Vitamin K antagonist
    Pros
    •Each strength of tablet is a unique color, making it easy to tell them apart
    •Only needs to be taken once a day
    •Has an antidote available in case of an emergency
    •Available as a lower-cost generic
    Cons
    •Only prevents new blood clots from forming or getting bigger; it doesn't work on existing blood clots
    •Requires regular blood draws to check INR levels
    •Interacts with foods and many commonly-prescribed medications
    •Not safe to take during pregnancy

  • Common Side Effects of Lodine vs. Coumadin

    Common Side Effects for

    The following side effects were reported in 1% to 10% of people who took etodolac:

    •Stomach pain
    •Indigestion or heartburn
    •Nausea
    •Vomiting
    •Constipation
    •Diarrhea
    •Passing gas
    •Stomach ulcer
    •Stomach bleeding
    •Swelling
    •Headache
    •Ringing in the ears
    •Itching
    •Rash
    •Anemia (low red blood cell count)
    •Elevated liver enzymes
    Common Side Effects for
    •Bleeding
    •Bruising

  • Warnings of Lodine vs. Coumadin

    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions and skin reactions
    •Not safe to take while pregnant
    •Risk for bleeding
    Common Side Effects for
    •Severe or life-threatening bleeding
    •Risk of blood clots from stopping too early
    •Risk of fat-containing clots
    •Calcium build-up in blood vessels (calciphylaxis)
    •Skin or tissue death and risk of gangrene
    •Not for use during pregnancy

  • Prices with our coupons for Lodine vs. Coumadin

    Learn more about Etodolac
    Learn more about Warfarin

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