Lodine vs. Warfarin for Pain and Deep Vein Thrombosis: Important Differences and Potential Risks.

Etodolac

Warfarin

(Coumadin)

Summary for Lodine

Prescription only

Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

Indications for Lodine

Osteoarthritis (OA)
Rheumatoid arthritis (RA)
Juvenile idiopathic arthritis - extended-release only
Short-term pain - immediate-release only

Pros and Cons for Lodine

Pros

Works well to treat pain and inflammation
Extended-release tablets can be used for children as young as 6 years old
Available as a lower-cost generic

Cons

Only available as pills that can't be split, open, or crushed
Not safe to take after 20 weeks of pregnancy
Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems

Common Side Effects for Lodine

The following side effects were reported in 1% to 10% of people who took etodolac:

Stomach pain
Indigestion or heartburn
Nausea
Vomiting
Constipation
Diarrhea
Passing gas
Stomach ulcer
Stomach bleeding
Swelling
Headache
Ringing in the ears
Itching
Rash
Anemia (low red blood cell count)
Elevated liver enzymes

Warnings for Lodine

Stomach bleeding
Heart attack and stroke
High blood pressure and heart failure
Kidney damage
Liver problems
Severe allergic reactions and skin reactions
Not safe to take while pregnant
Risk for bleeding

Summary for Warfarin

Prescription only

Warfarin (Coumadin) is a blood thinner (anticoagulant). It's used to prevent and treat blood clots in adults and children with conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE). Warfarin (Coumadin) is taken by mouth, typically once daily. Your provider will adjust the dose based on your international normalized ratio (INR). Taking too much warfarin (Coumadin) can lead to side effects like bruising and serious bleeding. If needed, your provider can give you an antidote to reverse the effects of warfarin (Coumadin).

Indications for Warfarin

Prevention and treatment blood clots in the veins
Prevention and treatment blood clots linked to atrial fibrillation (AFib) or heart valve replacement
Prevention of more blood clots and to lower risk of death after a heart attack

Pros and Cons for Warfarin

Pros

Each strength of tablet is a unique color, making it easy to tell them apart
Only needs to be taken once a day
Has an antidote available in case of an emergency
Available as a lower-cost generic

Cons

Only prevents new blood clots from forming or getting bigger; it doesn't work on existing blood clots
Requires regular blood draws to check INR levels
Interacts with foods and many commonly-prescribed medications
Not safe to take during pregnancy

Common Side Effects for Warfarin

Bleeding
Bruising

Warnings for Warfarin

Severe or life-threatening bleeding
Risk of blood clots from stopping too early
Risk of fat-containing clots
Calcium build-up in blood vessels (calciphylaxis)
Skin or tissue death and risk of gangrene
Not for use during pregnancy

Prices with our coupons for Lodine vs. Warfarin

Etodolac60 tablets / 400mg

$25.84$78.79

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Warfarin30 tablets / 5mg

$4.00$4.00

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Lodine vs. Warfarin

Etodolac

Warfarin

Summary for Lodine

Indications for Lodine

Pros and Cons for Lodine

Pros

Cons

Common Side Effects for Lodine

Warnings for Lodine

Summary for Warfarin

Indications for Warfarin

Pros and Cons for Warfarin

Pros

Cons

Common Side Effects for Warfarin

Warnings for Warfarin

Prices with our coupons for Lodine vs. Warfarin

Compare other Pain and Deep Vein Thrombosis drugs

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Etodolac

Warfarin

Summary for Lodine

Indications for Lodine

Pros and Cons for Lodine

Pros

Cons

Common Side Effects for Lodine

Warnings for Lodine

Summary for Warfarin

Indications for Warfarin

Pros and Cons for Warfarin

Pros

Cons

Common Side Effects for Warfarin

Warnings for Warfarin