Popular Proton Pump Inhibitors List, Drug Prices and Medication Information

Key takeaways

Proton pump inhibitors (PPIs) are used to treat gastroesophageal reflux disease (GERD), stomach ulcers, and erosive esophagitis. They also have other uses, such as managing Zollinger-Ellison syndrome. PPIs work by reducing the amount of acid your stomach makes, which helps to relieve symptoms and promote healing. These medications come in different forms, including oral pills and some injectable options. Examples include pantoprazole (Protonix), omeprazole (Prilosec, Prilosec OTC), and esomeprazole (Nexium).

Prices for popular Proton Pump Inhibitors medications

Viewing 13 of 13 medications

Protonix (pantoprazole)

as low as$11

Pantoprazole (Protonix) is an inexpensive drug used to treat gastroesophageal reflux disease, inflammation of the esophagus, and Zollinger-Ellison syndrome. This drug is slightly more popular than comparable drugs. It is available in brand and generic form. Generic pantoprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Prilosec (omeprazole)

as low as$14

Omeprazole (Prilosec) is an inexpensive drug used to treat certain conditions where there is too much acid in the stomach, like ulcers and gastroesophageal reflux disease (GERD). It is more popular than comparable drugs. It is available in both generic and brand versions, and without a prescription. Generic omeprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Nexium (esomeprazole)

as low as$121

Nexium (esomeprazole) is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, and inflammation of the esophagus. It can also be used to prevent ulcers in patients taking medicines called NSAIDs. Esomeprazole is more popular than other proton pump inhibitors. It is available in brand and generic versions.

Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Generic esomeprazole is covered by most Medicare and insurance plans.

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Konvomep

as low as$5

Konvomep (omeprazole/sodium bicarbonate) is used to treat active benign gastric ulcers and used to reduce the risk of upper gastrointestinal bleeding. There are currently no generic alternatives for Konvomep. It may be covered by your Medicare or insurance plan, but some pharmacy coupons or cash prices could help offset the cost.

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Prevacid (lansoprazole)

as low as$13

Lansoprazole (Prevacid) is a moderately priced drug used to treat GERD, heartburn, gastric ulcer, and duodenal ulcer. It works by reducing acid in the stomach. It is slightly more popular than comparable drugs. It is available in generic and brand versions. Generic lansoprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Prevacid 24Hr (lansoprazole 24hr)

as low as$13

Prevacid 24HR is the over-the-counter version of prescription Prevacid (lansoprazole), though the two are not considered equivalent. It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. Generic lansoprazole is also available over the counter.

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Zegerid OTC (omeprazole / sodium bicarbonate OTC)

as low as$15

Zegerid OTC is the over-the-counter version of prescription Zegerid (omeprazole/sodium bicarbonate), though the two are not considered equivalent. It is a proton pump inhibitor (PPI) used to treat frequent heartburn by reducing the acid in the stomach. There is currently no generic version available over the counter.

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Prilosec OTC (omeprazole OTC)

as low as$20

Prilosec is used to treat frequent heartburn by reducing the acid in the stomach. This version of Prilosec is available over the counter; however, to receive the discounted prices below, you will need to present a doctor’s prescription and purchase at the pharmacy counter.

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Aciphex (rabeprazole DR)

as low as$25

RABEPRAZOLE treats heartburn, stomach ulcers, reflux disease, or other conditions caused by too much stomach acid. It works by reducing the amount of acid in the stomach. It belongs to a group of medications called PPIs.

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Zegerid (omeprazole / sodium bicarbonate)

as low as$38

Omeprazole/sodium bicarbonate (Zegerid) is an expensive drug used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). This drug is slightly less popular than comparable drugs. It is available in brand and generic versions. It is not covered by most Medicare and insurance plans, but some manufacturer and pharmacy coupons can help offset the cost.

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Nexium 24Hr (esomeprazole non-prescription)

as low as$65

ESOMEPRAZOLE treats heartburn, stomach ulcers, reflux disease, or other conditions that cause too much stomach acid. It works by reducing the amount of acid in the stomach. It belongs to a group of medications called PPIs.

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Dexilant (dexlansoprazole)

as low as$142

Dexilant (dexlansoprazole) is used to treat GERD and heartburn. Dexilant is a proton pump inhibitor, which works by healing the esophagus and decreasing the amount of acid produced by the stomach. The most common form of Dexilant is a 60mg capsule. It is also available as 30mg capsules and 30mg orally disintigrating tablets. It is available in both generic and brand versions. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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esomeprazole sodium

as low as$197

ESOMEPRAZOLE treats reflux disease and other conditions that cause too much stomach acid. It works by reducing the amount of acid in the stomach. It belongs to a group of medications called PPIs.

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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.