Key takeaways
Protonix (pantoprazole) is a medication that treats conditions in which your body creates too much stomach acid, such as gastroesophageal reflux disease (GERD). Pepcid AC (famotidine) is a medication approved to treat heartburn. Protonix is a proton pump inhibitor (PPI), and it’s available by prescription only. Pepcid AC is a histamine-2 antagonist, and it’s available over the counter. Other forms of Pepcid are available by prescription and are approved to treat other conditions, including GERD. Both medications can cause stomach-related side effects such as nausea and diarrhea. But PPIs like Protonix may have more long-term side effects to consider, such as low vitamin B12 and magnesium levels, kidney problems, and bone fractures.
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