Key takeaways
Rabeprazole (Aciphex) and omeprazole (Prilosec) are both proton pump inhibitors (PPIs) used to treat conditions involving too much stomach acid, such as GERD and ulcers. Rabeprazole is available only by prescription, while omeprazole can be purchased over-the-counter (OTC) or by prescription. You typically take rabeprazole once a day, and it can be taken with or without food, depending on the condition being treated. Omeprazole is usually taken once daily 30 minutes before breakfast. Common side effects of either medication include constipation, passing gas, headaches, and stomach pain. Both medications can increase the risk of bone fractures and may cause kidney problems or serious skin reactions. However, omeprazole is also known to interact with a wider range of medications, such as clopidogrel (Plavix) and St. John’s wort, which can affect its effectiveness.
