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Compare Omeprazole vs. Mylanta Maximum Strength

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Omeprazole (Prilosec) and Mylanta Maximum Strength (aluminum hydroxide / magnesium hydroxide / simethicone) both medications that can ease heartburn. Omeprazole is a proton pump inhibitor (PPI), and Mylanta Maximum Strength is an antacid. For mild heartburn, it’s usually best to try an antacid before a PPI, which are known to have more risks than antacids. Antacids also work more quickly than PPIs. However, if your heartburn is happening more than twice a week, or if you have a condition like gastroesophageal reflux disease (GERD), antacids aren’t the best choice. In these cases, PPIs such as Prilosec may be a better option.

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