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Compare Zegerid vs. Mylanta Maximum Strength

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zegerid (omeprazole/sodium bicarbonate) and Mylanta Maximum Strength (aluminum hydroxide/magnesium hydroxide/simethicone) are both used to treat heartburn and related symptoms, but they belong to different medication classes. Zegerid is a combination of a proton pump inhibitor (PPI) and an antacid, while Mylanta Maximum Strength is a combination of antacids and an antiflatulent. Zegerid is available both over-the-counter and by prescription and is used for conditions like stomach ulcers, GERD, and erosive esophagitis. Mylanta Maximum Strength is available over-the-counter and is used for short-term relief of heartburn, sour stomach, indigestion, and gas. Zegerid is typically taken once daily on an empty stomach, while Mylanta Maximum Strength can be taken multiple times a day as needed. Zegerid can cause side effects like headache and stomach pain, while Mylanta Maximum Strength can cause diarrhea and nausea. Both can interact with other medications. Zegerid contains sodium and may not be recommended for those on a low-sodium diet, while Mylanta Maximum Strength contains magnesium and may not be recommended for those with kidney problems. Your pharmacist or prescriber can help determine the best medication for you.

  • Zegerid (omeprazole / sodium bicarbonate)
    Mylanta maximum strength
  • Zegerid (omeprazole / sodium bicarbonate)
    Mylanta maximum strength

  • Summary of Zegerid vs. Mylanta Maximum Strength

    Summary for PPI / Antacid

    Zegerid (omeprazole / sodium bicarbonate) is a combination medication used to treat conditions related to having too much stomach acid. This medication is typically taken by mouth once daily. But don't take it longer than what your provider recommends. Doing so raises your risk for side effects, such as bone fractures or low magnesium levels. Zegerid (omeprazole / sodium bicarbonate) is available as a powder that can be made into a liquid suspension for people who have trouble swallowing pills.

    Summary for Antacid / Antiflatulent

    Mylanta Maximum Strength is a combination medication containing three active ingredients: two antacids (aluminum hydroxide and magnesium hydroxide) and a gas medication (simethicone). It's used to help relieve the symptoms of heartburn, acid reflux, and gas. This medication is available over the counter (OTC) as a liquid for people ages 12 years and older. The dosage is 10 to 20 mL taken by mouth in between meals and at bedtime as needed. Possible side effects include diarrhea and nausea.

  • Indications of Zegerid vs. Mylanta Maximum Strength

    Indications for

    Prescription-strength Zegerid (omeprazole / sodium bicarbonate) capsules and suspension:

    •Stomach ulcer
    •Duodenal (first part of small intestine) ulcer
    •Heartburn and other symptoms related gastroesophageal reflux disease (GERD)
    •Erosive esophagitis (inflammation of the esophagus) due to GERD
    •Lower the risk of stomach bleeding in hospitalized people (suspension only)

    OTC Zegerid (omeprazole / sodium bicarbonate) capsules:

    •Frequent heartburn

    Konvomep (omeprazole / sodium bicarbonate) suspension:

    •Stomach ulcer
    •Lower the risk of stomach bleeding in hospitalized people
    Indications for

    Short-term relief of:

    •Heartburn
    •Sour stomach
    •Indigestion
    •Gas (bloating, pressure, discomfort)

  • Pros and Cons of Zegerid vs. Mylanta Maximum Strength

    Pros and Const for PPI / Antacid
    Pros
    •Available over the counter
    •Packet form is a good option if you have trouble swallowing pills
    •Typically taken once daily
    •Available as lower-cost generics
    •Longer-lasting relief than some other medications for heartburn
    Cons
    •Takes 1 to 4 days to ease heartburn
    •Has sodium, so not a good option for people on sodium-restricted diets
    •Typically has to be taken on an empty stomach before meals for best results
    •Can interact with other medications
    •Long-term use can weaken your bones and cause low vitamin B12 and magnesium
    Pros and Const for Antacid / Antiflatulent
    Pros
    •Provides fast relief (within several minutes)
    •Can take multiples times throughout the day for continued symptom relief
    •Comes as a flavored suspension
    •Available as a lower-cost generic medication
    •Can be purchased over the counter (OTC), without a prescription
    Cons
    •Doesn't last as long as other types of heartburn medications
    •Can interfere with how well other medications are absorbed into the body
    •Might not be a good option for people with kidney problems or on a magnesium-restricted diet
    •Not recommended for use during pregnancy
    •Contains magnesium, so can cause diarrhea

  • Common Side Effects of Zegerid vs. Mylanta Maximum Strength

    Common Side Effects for
    •Headache (3-7%)
    •Stomach pain (2-5%)
    •Diarrhea (3-4%)
    •Nausea (2-4%)
    •Gas (3%)
    •Vomiting (2-3%)

    Please note: These side effects were reported in clinical trials by people who took omeprazole only. The side effects you experience from Zegerid (omeprazole / sodium bicarbonate) might differ.

    Common Side Effects for
    •Diarrhea
    •Nausea
    •Constipation

  • Warnings of Zegerid vs. Mylanta Maximum Strength

    Common Side Effects for
    •Follow up with provider needed
    •Kidney damage
    •Severe skin reactions
    •High sodium content
    •Acid and base out of balance (Milk-alkali syndrome)
    •Severe diarrhea
    •Bone fractures
    •Lupus
    •Interactions with other medications
    •Low vitamin B12 and magnesium levels
    •Small growths in the stomach
    Common Side Effects for
    •Toxicity from too much magnesium
    •Toxicity from too much aluminum

  • Prices with our coupons for Zegerid vs. Mylanta Maximum Strength

    Learn more about Zegerid
    Learn more about Mylanta maximum strength

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