Key takeaways
Zegerid (omeprazole/sodium bicarbonate) and cimetidine (Tagamet HB) are both used to treat conditions related to excess stomach acid. But they have several differences. Zegerid combines a proton pump inhibitor (PPI) and an antacid, which lowers stomach acid and protects the omeprazole from being broken down by stomach acid. Cimetidine, on the other hand, is a histamine H2 receptor antagonist (H2RA) that blocks acid production in the stomach. Zegerid is typically taken once daily, while cimetidine can be taken one to 4 times a day depending on the condition being treated. Zegerid and cimetidine are both available over-the-counter and by prescription. Zegerid can cause side effects like headache, stomach pain, and diarrhea, and long-term use can lead to bone fractures and low magnesium levels. Cimetidine has fewer side effects, such as headache and dizziness, but it interacts with many medications, which can be a concern. Both medications are available in generic forms.
