Key takeaways
Sucralfate (Carafate) and Zegerid (omeprazole/sodium bicarbonate) are both used to treat ulcers, but they work in different ways. Sucralfate is an antiulcer medication that forms a protective barrier over ulcers to help them heal, and it is taken up to 4 times a day on an empty stomach. In contrast, Zegerid (omeprazole/sodium bicarbonate) is a combination of a proton pump inhibitor (PPI) and an antacid, which reduces stomach acid and is typically taken once daily. Sucralfate is available only by prescription, while Zegerid can be found both over-the-counter and by prescription. Sucralfate has fewer side effects because it is not absorbed into the body, whereas Zegerid can cause more serious side effects like bone fractures and low magnesium levels with long-term use. Additionally, Zegerid contains sodium, which may not be suitable for those on a low-sodium diet.
