Key takeaways
Pantoprazole (Protonix) and omeprazole (Prilosec) are both proton pump inhibitor (PPI) medications. They’re FDA approved to treat gastroesophageal reflux disease (GERD) and other gastrointestinal conditions. Pantoprazole is available by prescription only, while several forms of omeprazole are available over the counter. Both medications are typically taken once a day. Usually, it’s best to take omeprazole without food. Pantoprazole tablets, however, can be taken with or without food. Omeprazole is known to have more drug interactions than pantoprazole, but they have similar side effects.
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