Key takeaways
Rabeprazole (Aciphex) and Esomeprazole (Nexium) are both proton pump inhibitors (PPIs) used to treat conditions caused by too much stomach acid, such as GERD and ulcers. Rabeprazole is available only by prescription, while Esomeprazole can be bought over-the-counter or with a prescription. You should take Rabeprazole with or without food, depending on your condition, but Esomeprazole should be taken an hour before meals. Rabeprazole is typically taken once a day, but Esomeprazole can be taken once or twice a day. Both medications can cause side effects like constipation, passing gas, headaches, and belly pain. Long-term use of either medication can increase the risk of bone fractures and lower vitamin B12 and magnesium levels. However, Esomeprazole has a significant interaction with clopidogrel (Plavix), which can raise the risk of blood clots, while Rabeprazole interacts with warfarin (Coumadin), increasing the risk of bleeding.
