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Pantoprazole Coupon - Pantoprazole 40mg tablet

pantoprazole

Generic Protonix
Used for Heartburn, GERD
Used for Heartburn, GERD

Pantoprazole (Protonix) is a proton-pump inhibitor (PPI). It's used to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children. It's also used to treat other conditions involving too much stomach acid, such as erosive esophagitis, in adults only. Pantoprazole (Protonix) is taken by mouth, typically once daily for most conditions. Some of the more common side effects of this medication include headache and diarrhea. Pantoprazole (Protonix) isn't available over-the-counter (OTC).

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on March 11, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
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What is Pantoprazole (Protonix)?

02:27
Featuring Nabila Ismail, PharmD
Reviewed by Cydnee Ng, PharmD, Alexandra Schwarz, MD | June 28, 2024

What is Pantoprazole (Protonix) used for?

How Pantoprazole (Protonix) works

Pantoprazole (Protonix) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production. This helps relieve heartburn and other stomach problems.

When does Pantoprazole (Protonix) start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsProtonix
Drug ClassProton pump inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

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Omeprazole or Pantoprazole? Understanding the Differences

Written by Sarah Lobello Pearson, PharmD
basics-icon

What are the side effects of Pantoprazole (Protonix)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (12%)
  • Diarrhea (9%)
  • Nausea (7%)
  • Belly pain (6%)
Please note: Side effect percentages are listed for adults with GERD.

Other Side Effects

  • Vomiting
  • Excessive gas
  • Dizziness
  • Joint pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe stomach pain or diarrhea
  • Kidney problems: urinating more or less than usual, fever, poor appetite
  • Lupus symptoms: joint pain, skin rash on arms or cheeks that gets worse in the sunlight
  • Serious skin reactions: blistering, peeling, or bleeding skin, fever, chills
When do Pantoprazole (Protonix) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Headaches
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Pantoprazole (Protonix) side effects

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8 Protonix Side Effects You Should Know About

Written by Sarah Lobello Pearson, PharmD

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision

dry mouth

flushed, dry skin

fruit-like breath odor

increased hunger

increased thirst

increased urination

nausea

stomach pain

sweating

trouble breathing

unexplained weight loss

vomiting

Incidence not known

Absence of or decrease in body movements

blindness

blistering, peeling, or loosening of the skin

bloating

bloody or cloudy urine

bloody, black, or tarry stools

blurred vision

chills

clay-colored stools

constipation

continuous ringing or buzzing or other unexplained noise in the ears

cough

dark urine

decreased vision

diarrhea

difficulty with speaking

difficulty with swallowing

dizziness or lightheadedness

drowsiness

fast heartbeat

feeling of constant movement of self or surroundings

fever

general feeling of tiredness or weakness

greatly decreased frequency of urination or amount of urine

headache

hearing loss

high fever

hives, itching, or skin rash

indigestion

joint pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

light-colored stools

loss of appetite

mood or mental changes

muscle cramp, pain, or stiffness

muscle spasms (tetany) or twitching

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

seizures

sensation of spinning

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stomach pain, continuing

swelling of the feet or lower legs

swollen glands

tightness in the chest

trembling

unexplained bleeding or bruising

unpleasant breath odor

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Belching

bloated or full feeling

excess air or gas in the stomach or bowels

passing gas

trouble sleeping

Incidence not known

Increased watering of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Pantoprazole (Protonix)

thumbs-up

Pros

Can continue to use with antacids, such as calcium carbonate

Available as a lower-cost generic medication

Oral tablets can be taken without regard to food

Available in oral granules and suspension for people with trouble swallowing

thumbs-down

Cons

Long-term use might weaken bones and raise the risk of bone fractures

Might cause or worsen lupus

Interacts with warfarin (Coumadin), which can raise the risk of bleeding

Not available over-the-counter

pharmacist-tips

Pharmacist tips for Pantoprazole (Protonix)

pharmacist

  • Swallow the pantoprazole (Protonix) oral tablets whole. Don't chew or crush the tablets. Doing so can change how the medication gets absorbed into your body.

    • Typically, pantoprazole (Protonix) oral tablets can be taken with or without food. But pantoprazole (Protonix) oral granules and suspension should be taken 30 minutes before your meal.

      • Pantoprazole (Protonix) oral granules or suspension: Mix and stir the granules or suspension with 5 mL of applesauce. Take the entire dose within 10 minutes of mixing. Make sure to wash down the granules with water. Alternatively, you can mix the granules or suspension with 5 mL of apple juice. Make sure to drink the entire dose immediately. Rinse the cup 1 to 2 more times with apple juice to get all the remaining granules.

        • Pantoprazole (Protonix) can interact with many medications. Let your care team know what medications you take or plan to take. These medications include over-the-counter products and supplements. Talk with your care team if you have any questions about interactions with this medication.

          More on Pantoprazole (Protonix) tips

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          faqs

          Frequently asked questions about Pantoprazole (Protonix)

          Is pantoprazole (Protonix) over the counter?
          No, pantoprazole (Protonix) isn't available over the counter. You'll need a prescription from your HCP for this medication.
          Can I take pantoprazole (Protonix) twice a day?
          Pantoprazole (Protonix) is typically taken once daily. But for certain medical conditions that cause too much stomach acid (e.g., Zollinger-Ellison syndrome), you may take pantoprazole (Protonix) twice a day. Don't stop, start, or change how your take pantoprazole (Protonix) on your own without first speaking to your care team.
          How long does pantoprazole (Protonix) take to work?
          How long it takes for pantoprazole (Protonix) to work can differ for each person, depending on what condition you have and how severe your symptoms. In general, people who take this medication notice their heartburn or GERD symptoms getting better 2 to 6 hours after a dose. But it might take a few days to feel a more noticeable effect. If you're looking for more immediate relief, ask your healthcare professional (HCP) about taking quicker-acting antacids, such as Tums, along with pantoprazole (Protonix) until the medication effect kicks in.
          How long should I take pantoprazole (Protonix)?
          In general, your primary care provider (PCP) will recommend that you take pantoprazole (Protonix) for the shortest amount of time needed to treat your condition. While more research is needed, some evidence suggests that taking PPIs long-term might raise the risk of serious side effects, such as bone fractures. For most conditions, your HCP will only prescribe pantoprazole (Protonix) for up to 2 months. But sometimes, you might need to take this medication for a longer period of time. Talk with your care team if you're not sure how long you should take pantoprazole (Protonix).
          When to take pantoprazole (Protonix)?
          You can take pantoprazole (Protonix) oral tablets with or without food at any time of the day. On the other hand, pantoprazole (Protonix) oral granules and suspension work better if you take them 30 minutes before your meal.
          Can pantoprazole (Protonix) cause depression and anxiety?
          A few studies suggest that taking PPIs, like pantoprazole (Protonix), might be linked to depression and anxiety. In general, people who took a PPI daily for 4 months or longer were more likely to report these mental health conditions. More research is needed to understand the link between PPIs and mental health. But one possible explanation is that PPIs, like pantoprazole (Protonix), lower stomach acid. This can change the make up of the bacteria in the gut, which might affect your mood. Let your primary care HCP or psychiatrist know if you experience symptoms of depression or worsening mood while taking pantoprazole (Protonix).
          Does pantoprazole (Protonix) cause weight gain?
          Though rare, some studies show that people who took PPIs have reported weight gain. But it's unclear whether the weight gain was caused by PPIs, like pantoprazole (Protonix), or by other factors. Let your HCP know if you notice any unexpected changes in your weight because this might be symptom of other side effects of pantoprazole (Protonix) that might require more medical attention, including stomach problems, kidney problems, or infectious diarrhea. Talk with your HCP if you're concerned about pantoprazole (Protonix) and weight changes.
          Is pantoprazole (Protonix) the same as omeprazole (Prilosec)?
          Pantoprazole (Protonix) and omeprazole (Prilosec) are both PPIs used to lower stomach acid, but they aren't the same. One main difference is that omeprazole (Prilosec) is available both over the counter (OTC) and by prescription, while pantoprazole (Protonix) is prescription only. Another difference is that omeprazole (Prilosec) is FDA-approved to treat a few more conditions, such as Helicobacter pylori (H. pylori) infection, compared to pantoprazole (Protonix). Lastly, omeprazole (Prilosec) has more medication interactions than pantoprazole (Protonix). The American College of Gastroenterology doesn't recommend one over another when it comes to treating GERD symptoms. Your care team can help you decide if one PPI might be more appropriate for you.
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          warings-icon

          What are the risks and warnings for Pantoprazole (Protonix)?

          Pantoprazole (Protonix) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Risk of hiding symptoms of a more serious problem

          Frequent episodes of heartburn can be a symptom of stomach cancer. If your heartburn gets worse or comes back after taking pantoprazole (Protonix), let your healthcare professional (HCP) know. Also contact your HCP if you have poor appetite, unexplained weight loss, or weakness along with your heartburn. They can check if there are other serious medical problems going on.

          risk-warning

          Sudden kidney problems

          Some people taking PPIs like pantoprazole (Protonix) have had sudden kidney problems. These problems can happen at any point during treatment. Talk with your HCP if you're urinating more or less than usual, feel nauseous or weak, or have a fever, rash, or joint pain. These can be symptoms of kidney problems.

          risk-warning

          Severe infectious diarrhea

          • Risk factors: Older people | Recent stay at a hospital or nursing home | People with a weakened immune system (e.g., HIV, cancer)

            Some clinical studies showed that PPIs, such as pantoprazole (Protonix), can raise the risk of getting a bacterial infection called Clostridioides difficile (C. diff). This infection can cause severe diarrhea. Your risk is higher if you're over 65 years old, have recently stayed at a hospital or nursing home, or have a weakened immune system. To lower your risk of C. diff diarrhea, take the lowest possible dose of pantoprazole (Protonix) for the shortest amount of time that works well for you. If you experience severe or watery diarrhea, fever, belly pain, loss of appetite, or nausea, let your primary care provider know right away.

            risk-warning

            Bone fractures

            • Risk factors: Taking high doses of pantoprazole (Protonix) | Taking pantoprazole (Protonix) for longer than a year | Risk for osteoporosis

              PPIs like pantoprazole (Protonix) might raise the risk of bone fractures in the hip, wrist, or spine. Your risk is higher if you take more than one dose of pantoprazole (Protonix) per day or if you take it for more than a year. To prevent the risk of bone fractures, take the lowest possible dose of pantoprazole (Protonix) for the shortest amount of time for your symptoms. If you've had bone fractures before or have osteoporosis (weak bones), talk to your provider about your risk before using this medication.

              risk-warning

              Skin reactions

              PPIs, such as pantoprazole (Protonix), have rarely caused serious skin reactions. These reactions include Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Symptoms can include fever, body aches, rash, peeling skin, painful blisters, and swelling of the face. If you notice any of these symptoms, get medical help immediately.

              risk-warning

              Lupus

              Some people taking PPIs like pantoprazole (Protonix) developed new or worsening lupus, a condition where your immune system attacks your own body. Lupus symptoms can occur any time during treatment with pantoprazole (Protonix). Some typical symptoms include joint pain or rash, but they often improve within 1 to 3 months of stopping this medication. If you experience any lupus symptoms while taking pantoprazole (Protonix), stop the medication and contact your provider.

              risk-warning

              Low vitamin B12 and magnesium levels

              • Risk factor: Long-term use | Taking medications that can lower magnesium levels

                Using acid-lowering medications like pantoprazole (Protonix) for a long period of time can cause your vitamin B12 levels to drop. Pantoprazole (Protonix) lowers the amount of acid in your stomach, which is needed for vitamin B12 absorption. If you've been taking this medication for longer than 3 years, or if you have symptoms of vitamin B12 deficiency (e.g., dizziness, muscle weakness, pale skin, tiredness, tingling in arms or legs), talk to your primary care provider.

                Taking pantoprazole (Protonix) can also lower your magnesium levels. This can happen 3 months after taking pantoprazole (Protonix), but it's more likely after a year of treatment. Low magnesium levels can sometimes lead to other electrolyte problems. You're at risk for low magnesium levels if you take other medications that can affect electrolyte levels, such as digoxin (Lanoxin) or water pills. Your primary care provider might check your blood during treatment with pantoprazole (Protonix) to make sure your electrolyte levels are in the normal range. Watch for symptoms of electrolyte problems like irregular heart rate, muscle cramps, and tremors. Let your primary care provider know right away if they occur.

                risk-warning

                Interaction with other medications

                Pantoprazole (Protonix) can interfere with how other medications work. An important interaction to note is with pantoprazole (Protonix) is Edurant (rilpivirine), a medication that treat human immunodeficiency virus (HIV). Pantoprazole (Protonix) can lower the amount of Edurant (rilpivirine) in your body and cause the medication to not work as well, which can lead to virus spreading in your body. Make sure to avoid taking these medications together.

                In addition, pantoprazole (Protonix) can also interact with warfarin (Coumadin), which can raise your risk of abnormal bleeding. Your provider will monitor your bloodwork (e.g., INR) to make sure these medications are safe to take together. Watch out for nosebleeds, dizziness, unusual bruising, or bleeding from cuts that take a long time to stop.

                Finally, pantoprazole (Protonix) can raise the risk of methotrexate toxicity when taken together with methotrexate.

                risk-warning

                Inaccurate lab work

                Pantoprazole (Protonix) can get in the way of certain tumor screenings or drug testing, which can lead to inaccurate results. Talk with your HCP or radiologist about your medication history before getting any testing done. In some cases, your care team might ask you to temporarily stop pantoprazole (Protonix) 2 weeks before your blood work.

                dosage

                Pantoprazole (Protonix) dosage forms

                The average cost for 30 tablets of 40mg of Pantoprazole (Protonix) is $6.87 with a free GoodRx coupon. This is 88.34% off the average retail price of $58.91.
                carton
                Carton
                DosageQuantityPrice as low asPrice per unit
                30 packets of 40mg1 carton$113.51$113.51
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                20mg30 tablets$6.60$0.22
                40mg30 tablets$6.87$0.23

                Typical dosing for Pantoprazole (Protonix)

                Pantoprazole (Protonix) is available by prescription as oral tablets, suspension, and granules. It's also available as an injection that's administered into the veins by a provider in a healthcare setting.

                Adults

                • Gastroesophageal reflux disease (GERD): The typical dose is 40 mg by mouth once daily for up to 2 months. If needed, your care team might ask you to continue treatment for another 2 months.

                • Maintenance of healing of inflamed esophagus due to GERD: The typical dose is 40 mg by mouth once daily.

                • Medical conditions that cause too much stomach acid: The typical starting dose is 40 mg by mouth twice daily.

                Children ages 5 years and older

                • Gastroesophageal reflux disease (GERD): Your child's pediatrician will determine the dose based on their body weight.

                  • Weighing between 15 kg to less than 40 kg: The typical dose is 20 mg by mouth once daily for up to 2 months.

                  • Weighing 40 kg or more: The typical dose is 40 mg by mouth once daily for up to 2 months.

                More on Pantoprazole (Protonix) dosage forms

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                interactions

                Interactions between Pantoprazole (Protonix) and other drugs

                Pantoprazole (Protonix) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Pantoprazole (Protonix). Please note that only the generic name of each medication is listed below.

                More on Pantoprazole (Protonix) interactions

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                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                • Rilpivirine

                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                drug-cost

                How much does Pantoprazole (Protonix) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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                contraindications-icon

                Pantoprazole (Protonix) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Pantoprazole (Protonix) will not be safe for you to take.
                alternatives

                What are alternatives to Pantoprazole (Protonix)?

                There are a number of medications that your doctor can prescribe in place of Pantoprazole (Protonix). Compare a few possible alternatives below.
                Pantoprazole (Protonix)
                Used for:
                $6.60 Lowest GoodRx priceView Prices
                Esomeprazole (Nexium)
                Used for:

                • Heartburn — OTC only

                • Lower the risk of stomach ulcer due to nonsteroidal anti-inflammatory drugs (NSAID)

                • Lower the risk of duodenal ulcer caused by Helicobacter pylori (H. pylori) infection

                • Other medical conditions that cause too much stomach acid (e.g., Zollinger-Ellison syndrome)

                • Gastroesophageal reflux disease (GERD)

                • Inflamed esophagus due to GERD

                $13.16 Lowest GoodRx priceView Prices
                Lansoprazole (Prevacid)
                Used for:
                $11.60 Lowest GoodRx priceView Prices
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                What is the latest news about Pantoprazole (Protonix)?

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                images

                Pantoprazole (Protonix) images

                Yellow Oval M P9 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "M P9".Yellow Oval M P9 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                White Oval 97 - Pantoprazole Sodium 40mg Delayed-Release Tablet
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                Yellow Oval H126 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "H126".Yellow Oval H126 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                Yellow Round 124 - Pantoprazole Sodium 40mg Delayed-Release Tablet
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                Yellow Round R333 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Round Tablet Imprinted With "R333".Yellow Round R333 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                White Oval 17 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is White, Oval Tablet Imprinted With "17".White Oval 17 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                White Oval Ku 181 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is White, Oval Tablet Imprinted With "Ku 181".White Oval Ku 181 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                White Oval 17 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is White, Oval Tablet Imprinted With "17".White Oval 17 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                Yellow Oval I 52 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "I 52".Yellow Oval I 52 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                Yellow Oval G73 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "G73".Yellow Oval G73 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                Yellow Oval G73 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Oval Tablet Imprinted With "G73".Yellow Oval G73 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                Yellow Round R333 - Pantoprazole Sodium 40mg Delayed-Release Tablet
                This medicine is Yellow, Round Tablet Imprinted With "R333".Yellow Round R333 - Pantoprazole Sodium 40mg Delayed-Release Tablet

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                References

                Best studies we found

                American Cancer Society. (2021). Signs and Symptoms of Stomach Cancer.

                Ajanta Pharma USA Inc. (2023). PANTOPRAZOLE SODIUM - pantoprazole sodium for suspension [package insert]. DailyMed.

                Bernshteyn, M.A., et al. (2023). Pantoprazole. StatPearls.

                View All References (9)

                Centers for Disease Control and Prevention. (n.d.). What is C. diff?.

                Edenbridge Pharmaceuticals LLC. (2023). PANTOPRAZOLE SODIUM - pantoprazole sodium granule, delayed release [package insert]. DailyMed.

                Eugia US LLC. (2023). PANTOPRAZOLE SODIUM injection, powder, for solution [package insert]. DailyMed.

                Katz, P.O., et al. (2022). ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. The American Journal of Gastroenterology.

                Liang, J.F., et al. (2015). Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan. Cephalalgia.

                NorthStar RxLLC. (2023). PANTOPRAZOLE- pantoprazole tablet, delayed release [package insert]. DailyMed.

                Office of Dietary Supplements. (2021). Vitamin B12. National Institutes of Health.

                Sagent Pharmaceuticals. (2023). PANTOPRAZOLE SODIUM- pantoprazole sodium injection, powder, lyophilized, for solution [package insert]. DailyMed.

                Wang, Y., et al. (2022). Proton pump inhibitor use and risk of depression and anxiety in children: nationwide cohort study. Clinical and Translational Science.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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