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Nexium (esomeprazole) is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, and inflammation of the esophagus. It can also be used to prevent ulcers in patients taking medicines called NSAIDs. Esomeprazole is more popular than other proton pump inhibitors. It is available in brand and generic versions.
Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Generic esomeprazole is covered by most Medicare and insurance plans.
Get Esomeprazole for as low as $10.20, which is 94% off the average retail price of $179.80 for the most common version, by using a GoodRx coupon.

| Dosage | Quantity | Retail price | GoodRx price |
|---|
| Dosage | Quantity | Retail price | GoodRx price |
|---|
| 20mg | 90 capsules | $716.81 | $31.79 |
| 40mg | 30 capsules | $213.00 | $11.37 |
| 30 packets of 2.5mg | 1 carton | $292.96 | $72.59 |
| 30 packets of 5mg | 1 carton | $292.89 | $72.59 |
| 30 packets of 10mg | 1 carton | $292.98 | $63.19 |
| 30 packets of 20mg | 1 carton | $214.69 | $74.02 |
| 30 packets of 40mg | 1 carton | $292.82 | $87.62 |
GoodRx coupon prices last updated on 03/16/26.
Sales tax may apply and is not included.