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Viberzi Coupon - Viberzi 100mg tablet

Viberzi

eluxadoline
Used for Irritable Bowel Syndrome
Used for Irritable Bowel Syndrome

Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It works on the opioid receptor to help ease symptoms such as stomach pain and diarrhea. You typically take a dose by mouth twice a day with food. Because of its potential for misuse and dependence, it’s considered a controlled substance. Common side effects include constipation, nausea, and stomach pain.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on April 15, 2025
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
Viberzi (eluxadoline) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Viberzi (eluxadoline)?

What is Viberzi (eluxadoline) used for?

How Viberzi (eluxadoline) works

Viberzi (eluxadoline) is an opioid receptor agonist/antagonist, which means it attaches to different types of opioid receptors in your body. While experts aren’t exactly sure how it works, it's thought to reduce gut sensitivity and slow down how food moves through your intestines. This can help relieve stomach pain and diarrhea in people with IBS-D.

When does Viberzi (eluxadoline) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsViberzi
Drug ClassOpioid receptor agonist/antagonist
Controlled Substance ClassificationSchedule IV
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$1939.37(save 15.72%)
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$1634.41
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What are the risks and warnings for Viberzi (eluxadoline)?

Viberzi (eluxadoline) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Pancreatitis

  • Risk factors: Not having a gallbladder | Drinking excessive alcohol

    Viberzi (eluxadoline) can cause pancreatitis, which is inflammation of the pancreas. This side effect is more likely in people without a gallbladder, and in some cases, it has been severe or even deadly. Because of this, you shouldn't use Viberzi (eluxadoline) if you don’t have a gallbladder. Most cases of pancreatitis happened within the first week of starting this medication, sometimes after only one or two doses.

    If you do have a gallbladder, your prescriber will review your alcohol use before starting Viberzi (eluxadoline). Avoid drinking too much alcohol while taking this medication since doing so can raise your risk of pancreatitis. Watch for symptoms like severe stomach pain that spreads to your back or shoulder, with or without nausea or vomiting. If you notice any of these symptoms, stop taking this medication right away and get medical help.

    risk-warning

    Bile duct muscle spasm

    • Risk factors: Not having a gallbladder

      Viberzi (eluxadoline) can cause a muscle spasm in the bile duct area (called sphincter of Oddi spasm), which can lead to pancreatitis or liver problems. This is more likely in people without a gallbladder. This spasm can cause sudden stomach pain, especially in the upper right side, and the pain can spread to your back or shoulder. You might also feel nausea or vomiting. Most cases happen within the first week of starting this medication, even after just one or two doses.

      risk-warning

      Allergic reactions

      Viberzi (eluxadoline) can cause allergic reactions, including some that were life-threatening, sometimes after just the first or second dose. If you have a rash, itching, swelling, trouble breathing, or dizziness, stop taking Viberzi (eluxadoline) and contact your prescriber right away.

      risk-warning

      Constipation

      • Risk factors: Also taking other medications that cause constipation

        Constipation has been reported in people taking Viberzi (eluxadoline), and in some cases, it has been severe enough to require hospitalization. Rarely, it has led to serious problems like intestinal blockage, a tear in the intestine, or stool buildup that needed medical treatment. Stop taking Viberzi (eluxadoline) and contact your prescriber right away if you experience severe constipation. Avoid taking Viberzi (eluxadoline) with other medications that can cause constipation.

        basics-icon

        What are the side effects of Viberzi (eluxadoline)?

        The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

        Common Side Effects

        Other Side Effects

        Serious Side Effects

        Contact your healthcare provider immediately if you experience any of the following.
        • Pancreatitis: severe stomach pain that starts from your back or shoulder, nausea, vomiting, fever, foul-smelling stools
        • Bile duct muscle spasm: stomach pain, nausea, vomiting, yellowing of the whites of the eyes, yellowing of the skin
        • Serious allergic reactions: trouble breathing, rash, itching, hives; swelling of your face, lips, mouth or tongue
        • Severe constipation: severe stomach pain, rectal bleeding, vomiting, unable to have a bowel movement
        When do Viberzi (eluxadoline) possible side effects begin and end?
        Time passed since treatment started:
        HOURS
        DAYS
        WEEKS
        MONTHS
        Constipation
        Bile duct muscle spasm
        Pancreatitis
        Seek immediate medical care if you experience this side effect.

        Source: DailyMed

        More on Viberzi (eluxadoline) side effects

        Viberzi: side effects viberzi

        6 Viberzi Side Effects and How to Manage Them

        Written by Mandeep Sohal, PharmD

        The following side effects have also been reported

        Side effects that you should report to your care team as soon as possible:

        Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

        pros-and-cons

        Pros and cons of Viberzi (eluxadoline)

        thumbs-up

        Pros

        Tablet that's taken by mouth

        Typically works within a week

        Approved for males and females with IBS-D

        thumbs-down

        Cons

        Must be taken twice a day with food

        Is a controlled substance

        Risk of pancreatitis, inflammation of the pancreas

        pharmacist-tips

        Pharmacist tips for Viberzi (eluxadoline)

        pharmacist

        • Take Viberzi (eluxadoline) by mouth twice a day with food. You need to take it every day, not just when you have diarrhea or stomach pain.

          • If you have diarrhea while taking Viberzi (eluxadoline), you can use loperamide occasionally. But try not to take both medications long term since this could make you constipated.

            • If you miss a dose of Viberzi (eluxadoline), skip it and take your next dose at your regular time. Never take two doses at once.

              • If you get severe constipation while taking Viberzi (eluxadoline), stop taking it and contact your prescriber. Severe constipation can be dangerous and lead to blocked intestines or stool buildup.

                • Viberzi (eluxadoline) can cause pancreatitis, which is inflammation of the pancreas. Stop taking it and get medical help right away if you have severe stomach pain that might spread to your back or shoulder, with or without nausea and vomiting.

                  • Avoid drinking more than 3 alcoholic drinks a day while taking Viberzi (eluxadoline) since this can raise your risk of pancreatitis.

                    faqs

                    Frequently asked questions about Viberzi (eluxadoline)

                    Does Viberzi (eluxadoline) cause weight gain?
                    Weight gain isn't a common side effect of Viberzi (eluxadoline). But everyone reacts differently, and some people might notice changes in weight due to improved appetite or digestion. If you have unexpected weight gain while taking this medication, talk to your prescriber to see if it's related or if something else might be going on.
                    Is Viberzi (eluxadoline) an opioid?
                    Viberzi (eluxadoline) is considered an opioid receptor agonist/antagonist because it attaches to some of the same receptors as opioids — but it mostly works in the gut, not the brain. This helps relieve stomach pain and slow down digestion in people with IBS-D, but without the same level of risks than traditional opioids have.
                    How long does it take for Viberzi (eluxadoline) to work?
                    Viberzi (eluxadoline) starts to work soon after you take it, helping with stomach pain and diarrhea. The full effect can be seen within a week. But unlike some antidiarrheal medications, it needs to be taken every day, not just "as needed," to work properly.
                    Is Viberzi (eluxadoline) a controlled substance?
                    Yes, Viberzi (eluxadoline) is a controlled medication because it has a risk of misuse and dependence. This means there are rules about how it's prescribed, including limits on refills, how much you can get, and how often it can be filled.
                    Can Viberzi (eluxadoline) be cut in half?
                    No. Viberzi (eluxadoline) tablets aren't made to be cut in half — they're not scored for safe splitting. Cutting the tablet could change how the medication is absorbed and how well it works. If you're having trouble swallowing this medication, speak with your prescriber for guidance.
                    Does Viberzi (eluxadoline) cause hair loss?
                    Hair loss isn't a reported side effect of Viberzi (eluxadoline) in clinical studies. If you notice hair loss after starting this medication, speak with your prescriber — they can help figure out the cause.
                    Can you just stop taking Viberzi (eluxadoline)?
                    You shouldn't stop taking Viberzi (eluxadoline) without talking to your prescriber first. While it’s not known to cause withdrawal symptoms, stopping suddenly may cause your IBS-D symptoms (like diarrhea and stomach pain) to return. If you're thinking about stopping, talk to your prescriber about the best and safest way to do it.
                    Can you drink alcohol while taking Viberzi (eluxadoline)?
                    It’s best to avoid drinking too much alcohol while taking Viberzi (eluxadoline). Alcohol can raise your risk of serious side effects, especially pancreatitis, a dangerous inflammation of the pancreas. Because of this, people who have a history of alcohol use disorder or drink more than 3 alcoholic beverages per day shouldn't take this medication. Speak to your prescriber if you have more questions about drinking alcohol while taking Viberzi (eluxadoline).
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                    dosage

                    Viberzi (eluxadoline) dosage forms

                    The average cost for 60 tablets of 100mg of Viberzi (eluxadoline) is $1634.41 with a free GoodRx coupon. This is 15.72% off the average retail price of $1939.37.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    75mg60 tablets$1635.28$27.25
                    100mg60 tablets$1634.41$27.24

                    Typical dosing for Viberzi (eluxadoline)

                    The typical starting dose is 100 mg by mouth twice a day with food.

                    Your dose might be lower if you can't tolerate the 100 mg dose, are taking medications that interact with Viberzi (eluxadoline), or have kidney or liver problems.

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                    How much does Viberzi (eluxadoline) cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
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                    contraindications-icon

                    Viberzi (eluxadoline) contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Viberzi (eluxadoline) will not be safe for you to take.

                    • People without a gallbladder

                    • Biliary duct problems

                    • Alcohol use disorder or people who drink more than 3 alcoholic drinks per day

                    • Pancreas problems

                    • Serious liver problems

                    • History of long-term constipation or severe constipation

                    alternatives

                    What are alternatives to Viberzi (eluxadoline)?

                    There are a number of medications that your doctor can prescribe in place of Viberzi (eluxadoline). Compare a few possible alternatives below.
                    Viberzi (eluxadoline)
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                    images

                    Viberzi (eluxadoline) images

                    Pink-Orange Oblong Fx100 - Viberzi 100mg Tablet
                    This medicine is Pink-Orange, Oblong Tablet Imprinted With "Fx100".Pink-Orange Oblong Fx100 - Viberzi 100mg Tablet

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                    References

                    Best studies we found

                    Allergan, Inc. (2024). Viberzi- eluxadoline tablet, film coated [package insert]. DailyMed.

                    Crittenden, J. P., et al. (2023). Sphincter of Oddy dysfunction. StatPearls.

                    Dhaliwal, A., et al. (2023). Physiology, opioid receptor. StatPearls.

                    View All References (3)

                    Lembo, A. J., et al. (2016). Eluxadoline for irritable bowel syndrome with diarrhea. The New England Journal of Medicine.

                    Maltz, F., et al. (2017). Eluxadoline (Viberzi): A mu-opioid receptor agonist for the treatment of irritable bowel syndrome with diarrhea. Pharmacy and Therapeutics.

                    Wade, P. R., et al. (2012). Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist. British Journal of Pharmacology.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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