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Compare Ibsrela vs. Viberzi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ibsrela (tenapanor) and Viberzi (eluxadoline) are both prescription medications used to treat different types of irritable bowel syndrome (IBS). Ibsrela is used for IBS with constipation (IBS-C), while Viberzi is used for IBS with diarrhea (IBS-D). Ibsrela works by preventing sodium absorption in the gut, which helps soften stool and relieve constipation, and is taken twice daily before meals. On the other hand, Viberzi attaches to opioid receptors in the intestines to reduce abdominal pain and diarrhea and is also taken twice daily with food. Unlike Ibsrela, Viberzi is a controlled substance due to its potential for abuse and dependence. Common side effects of Ibsrela include diarrhea and bloating, whereas Viberzi can cause constipation and nausea. Additionally, Viberzi is not suitable for people without a gallbladder or those who consume more than three alcoholic drinks per day due to the risk of pancreatitis.

  • Ibsrela (tenapanor)
    Viberzi (eluxadoline)
  • Ibsrela (tenapanor)
    Viberzi (eluxadoline)

  • Summary of Ibsrela vs. Viberzi

    Summary for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Prescription only

    Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.

    Summary for Opioid receptor agonist/antagonist
    Prescription only

    Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It works on the opioid receptor to help ease symptoms such as stomach pain and diarrhea. You typically take a dose by mouth twice a day with food. Because of its potential for misuse and dependence, it’s considered a controlled substance. Common side effects include constipation, nausea, and stomach pain.

  • Indications of Ibsrela vs. Viberzi

    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults
    Indications for
    •Irritable bowel syndrome with diarrhea (IBS-D) in adults

  • Pros and Cons of Ibsrela vs. Viberzi

    Pros and Const for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Pros
    •Recommended for people with IBS-C who've already tried other therapies
    •Can help lessen episodes of stomach pain and constipation
    •Symptoms can start to improve within a week
    Cons
    •Need to take right before a meal twice daily
    •Can cause diarrhea and dehydration
    •Not safe for children
    Pros and Const for Opioid receptor agonist/antagonist
    Pros
    •Tablet that's taken by mouth
    •Typically works within a week
    •Approved for males and females with IBS-D
    Cons
    •Must be taken twice a day with food
    •Is a controlled substance
    •Risk of pancreatitis, inflammation of the pancreas

  • Common Side Effects of Ibsrela vs. Viberzi

    Common Side Effects for
    •Diarrhea (16%)
    •Stomach bloating (3%)
    •Gas (3%)
    •Dizziness (2%)
    Common Side Effects for
    •Constipation (8%)
    •Nausea (7%)
    •Stomach pain (7%)

  • Warnings of Ibsrela vs. Viberzi

    Common Side Effects for
    •Serious dehydration in children
    •Diarrhea
    Common Side Effects for
    •Pancreatitis
    •Bile duct muscle spasm
    •Allergic reactions
    •Constipation

  • Prices with our coupons for Ibsrela vs. Viberzi

    Learn more about Ibsrela
    Learn more about Viberzi

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