Medications for cold symptoms are used to relieve cough, reduce nasal congestion, and ease runny nose. Some of these medications also have other uses, such as treating allergies or motion sickness. They work by targeting different parts of your body to reduce symptoms. Common classes include antihistamines, decongestants, and cough suppressants. Antihistamines like doxylamine (found in NyQuil Cough) help reduce runny nose and sneezing. Decongestants such as pseudoephedrine (Sudafed) relieve nasal congestion. Cough suppressants like dextromethorphan (Delsym) help control coughing. Some medications, like hydrocodone / chlorpheniramine ER, combine these effects to provide more comprehensive relief. These medications are usually taken as oral pills or syrups, making them easy to use at home.