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Antihistamine / Opioid Combinations

Antihistamine / opioid combinations are used to treat cough and cold symptoms. They work by suppressing the cough and blocking histamine which causes the symptoms of stuffy nose, runny nose, itchy throat, and sneezing.

Why are antihistamine opioid combinations prescribed?

  1. Allergic Rhinitis (33%)
  2. Cold Symptoms (33%)
  3. Cough (33%)

Key takeaways

Antihistamine / opioid combinations are used to treat cough, cold symptoms, and allergies. These medications work by combining the effects of an antihistamine, which reduces allergy symptoms, and an opioid, which helps to suppress the cough reflex. These medications come in oral forms, such as tablets, capsules, and syrups. Examples include hydrocodone / chlorpheniramine (Tussionex, Tussicaps) and codeine / chlorpheniramine (Tuzistra XR, Tuxarin ER). You can discuss which option might be right for you with your healthcare team.

Prices for popular Antihistamine / Opioid Combinations medications
Viewing 6 of 6 medications
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hydrocodone / chlorpheniramine ER

as low as$13
HYDROCODONE; CHLORPHENIRAMINE treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, a runny or stuffy nose, and red, itchy eyes. It is a combination of an opioid cough suppressant and an antihistamine.
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tablet icon

Tuxarin ER

as low as$22
CHLORPHENIRAMINE; CODEINE is a combination of an antihistamine and cough suppressant. It is used to treat the symptoms of cough, allergies, and colds.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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oral-suspension icon

Tuzistra XR

as low as$79
CODEINE; CHLORPHENIRAMINE treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, a runny or stuffy nose, and red, itchy eyes. It is a combination of an opioid cough suppressant and an antihistamine.
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capsule icon

Tussicaps

as low as$356
CHLORPHENIRAMINE; HYDROCODONE is a combination of an antihistamine and cough suppressant. It is used to treat the symptoms of allergies and colds.\n \nThis medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
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hydrocodone / chlorpheniramine

Hydrocodone/Chlorpheniramine is part of the Antihistamine / Opioid Combinations class and treats Cold Symptoms and Cough. Antihistamine / opioid combinations are used to treat cough and cold symptoms. They work by suppressing the cough and blocking histamine which causes the symptoms of stuffy nose, runny nose, itchy throat, and sneezing. Hydrocodone/Chlorpheniramine is only available as a generic drug.
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oral-suspension icon

Tussionex

HYDROCODONE; CHLORPHENIRAMINE treats the symptoms of the common cold, allergies, or flu. It works by reducing cough, a runny or stuffy nose, and red, itchy eyes. It is a combination of an opioid cough suppressant and an antihistamine.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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