Opioid and phenothiazine combinations are used to treat cough, runny nose, and sneezing, which are often symptoms of allergies or the common cold. They also have other uses, such as managing anxiety and motion sickness. These medications work by combining an opioid (codeine), which helps to relieve pain and suppress cough, with a phenothiazine (promethazine), which is an antihistamine that treats symptoms like runny nose. Examples include promethazine/codeine.