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Tezspire vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tezspire (tezepelumab) and Dupixent (dupilumab) are both injectable biologic medications used to treat asthma, but they belong to different medication classes. Tezspire is a thymic stromal lymphopoietin (TSLP) blocker, while Dupixent is an interleukin antagonist. Tezspire is specifically approved for severe asthma in people aged 12 and older, whereas Dupixent is approved for moderate-to-severe asthma in people aged 6 and older, as well as other conditions like eczema and eosinophilic esophagitis. Tezspire is typically injected once a month by a healthcare professional, while Dupixent is usually injected every 1 to 4 weeks, depending on the condition being treated. Both medications are available as pre-filled pens and syringes. Tezspire has a low risk of side effects but can cause joint and back pain, while Dupixent can cause injection site reactions and eye inflammation. Both medications can cause serious allergic reactions and are not used to treat asthma attacks.

Tezspire

(tezepelumab)

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Dupixent

(dupilumab)

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Summary for Tezspire

Prescription only

Tezspire (tezepelumab or tezepelumab-ekko) is a biologic medication. It's used to treat severe asthma. It can also treat chronic rhinosinusitis (sinus inflammation) with nasal polyps (CRSwNP). Tezspire (tezepelumab) is for people ages 12 years and older and is added to treatment when other medications aren't enough. The dosage is given as an injection under the skin once a month. A trained healthcare professional can give the injection with the vials or prefilled syringes. There are also prefilled pens that you can use at home for your injections. Side effects aren't common but can include joint pain and a higher risk of infections.

Indications for Tezspire

Pros and Cons for Tezspire

Pros

Cons

  • Given as an injection under the skin
  • Might be hard for some people to inject properly
  • Only used as add-on therapy to other medications
  • Can raise the risk of infections

Common Side Effects for Tezspire

Asthma:

  • Sore throat (4%)
  • Joint pain (4%)
  • Back pain (4%)

Chronic rhinosinusitis with nasal polyps:

Warnings for Tezspire

  • Severe allergic reaction
  • Unknown effect on your immune response to parasitic worm infections
  • Avoid live vaccines

Summary for Dupixent

Prescription only

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

Indications for Dupixent

Pros and Cons for Dupixent

Pros

  • Taken every other week or monthly for most conditions
  • Approved for some children (specific age depends on the condition)
  • Available as prefilled pens (for people ages 2 years and older)
  • Available as prefilled syringes (for people ages 6 months and older)

Cons

  • Given as an injection under the skin
  • Not used for helping with asthma attacks
  • Can cause injection reactions, such as pain, bruising, and swelling
  • Unknown if it's safe or works well while pregnant or breastfeeding

Common Side Effects for Dupixent

  • Injection site reaction (e.g., pain, swelling, bruising; 10%)
  • Eye redness or eye inflammation (10%)
  • Cold sores (4%)

Warnings for Dupixent

  • Allergic reactions
  • Eye inflammation
  • Other inflammation in the body
  • Risk of worsening of breathing problems in people with asthma or COPD
  • Risk of psoriasis
  • Joint pain and psoriatic arthritis
  • Unknown effect in people with parasitic worm infections
  • Interaction with vaccines

Prices with our coupons for Tezspire vs. Dupixent

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Tezspire1 pen / 210mg of 210mg/1.91ml
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Dupixent2 cartons / 2 pens of 300mg/2ml
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