Key takeaways
Prezcobix (darunavir/cobicistat) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) are both antiretroviral medications used to treat HIV infections, but they have some key differences. Prezcobix combines a protease inhibitor (darunavir) and a booster (cobicistat), while Genvoya includes an integrase strand transfer inhibitor (elvitegravir), two nucleoside reverse transcriptase inhibitors (emtricitabine and tenofovir alafenamide), and a booster (cobicistat). Prezcobix is typically taken with other HIV medications, whereas Genvoya is a complete regimen on its own. Both medications are available only as a brand-name medication. Both medications need to be taken with food and are taken once daily. However, Genvoya has the risk of worsening hepatitis B if the medication is stopped suddenly. Prezcobix, on the other hand, has specific interactions with other medications and must be used carefully in people with sulfa allergies.
