Key takeaways
Myrbetriq (mirabegron) and Vesicare (solifenacin) are both used to treat overactive bladder (OAB), but they work in different ways and belong to different drug classes. Myrbetriq (mirabegron) is a beta-3 adrenergic agonist that helps your bladder relax so it can hold more urine, while Vesicare (solifenacin) is an anticholinergic and antimuscarinic that reduces bladder muscle spasms. Myrbetriq is available only as a brand name and can be taken by adults and children over 3 years old, whereas Vesicare has a generic version and can be used by adults and a liquid version for children over 2 years old. Common side effects of Myrbetriq include high blood pressure and urinary tract infections, while Vesicare often causes dry mouth and constipation. Myrbetriq is generally taken once a day and can be combined with Vesicare for better results. Vesicare should not be used if you have untreated narrow-angle glaucoma or certain gastrointestinal conditions. Both medications can cause serious side effects like angioedema, but Vesicare also carries a risk of heart rhythm problems and heat exhaustion.
