Key takeaways
Myrbetriq (mirabegron) and trospium (Sanctura) are both used to treat overactive bladder (OAB), but they work in different ways and have different side effects. Myrbetriq is a beta-3 adrenergic agonist that helps your bladder relax so it can hold more urine, and it's taken once daily. Trospium, on the other hand, is an antimuscarinic medication that blocks acetylcholine to relax the bladder muscles, and it comes in both immediate-release tablets taken twice daily and extended-release capsules taken once daily. Myrbetriq can cause high blood pressure and urinary tract infections, while trospium commonly causes dry mouth and constipation. Unlike Myrbetriq, which has no generic version, trospium is available in a generic form. Additionally, Myrbetriq can be taken with or without food, but trospium must be taken on an empty stomach. Both medications can cause serious side effects like angioedema, but trospium also has risks related to vision changes and nervous system effects.
