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Metaglip vs. Glyburide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glipizide/metformin (Metaglip) and glyburide (Glynase) are medications used to treat Type 2 diabetes. Both help lower blood sugar, but they have several differences between them. Glipizide/metformin is a combination of glipizide and metformin. Both medications work by telling your pancreas to release insulin, but glipizide/metformin also reduces the amount of sugar your body makes and absorbs. Glipizide/metformin is usually taken once or twice daily, and can cause side effects like diarrhea and lactic acidosis. Glyburide is taken once daily with the largest meal and can cause side weight gain. Unlike glipizide/metformin, glyburide has a formulation that is absorbed better by the body. Both medications are available as low-cost generics and carry risks of heart problems and low blood sugar, but glipizide/metformin also has an increased risk of low vitamin B12 levels.

Glipizide/metformin

 

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Glyburide

 

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Summary for Metaglip

Prescription only

Glipizide/metformin combines two diabetes medications into one tablet: glipizide (a sulfonylurea) and metformin (a biguanide). It's approved to treat Type 2 diabetes in adults along with diet and exercise. This medication is typically taken by mouth once or twice a day. Some common side effects of glipizide/metformin can include diarrhea and headache; it isn't likely to cause weight gain or weight loss.

Indications for Metaglip

Pros and Cons for Metaglip

Pros

  • Taken by mouth
  • Combination medication, so more convenient to take
  • Available as a lower-cost generic

Cons

  • Need to take with meals
  • Can't take during pregnancy
  • Not an option for children

Common Side Effects for Metaglip

  • Diarrhea (18%)
  • Headache (13%)
  • Cold or flu infection (10%)
  • Low blood sugar levels (9%)
  • Muscle pain (8%)
  • Nausea, vomiting (8%)
  • Stomach pain (6%)
  • Dizziness (5%)

Warnings for Metaglip

  • Lactic acidosis
  • Possible risk of serious heart problems
  • Low blood sugar levels
  • Low vitamin B12 levels

Summary for Glyburide

Prescription only

Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

Indications for Glyburide

  • Type 2 diabetes

Pros and Cons for Glyburide

Pros

  • Usually taken only once daily with largest meal
  • Can lower A1C levels by 1.5%
  • Taken by mouth, so good option for people who don't like injections
  • Can be taken with some other blood sugar medications, such as metformin

Cons

  • Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
  • More likely to cause low blood sugar than other blood sugar medications, such as metformin
  • Can cause some weight gain
  • Not approved for Type 1 diabetes

Common Side Effects for Glyburide

  • Feeling bloated
  • Nausea
  • Heartburn

Warnings for Glyburide

  • Low blood sugar (hypoglycemia)
  • Possible risk of heart problems
  • Breakdown of red blood cells

Prices with our coupons for Metaglip vs. Glyburide

Price Card Drug Icon
Glipizide/Metformin180 tablets / 5mg/500mg
$41.98$91.97
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Price Card Drug Icon
Glyburide180 tablets / 5mg
$25.93$69.63
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