Key takeaways
Kaletra (lopinavir/ritonavir) and Aptivus (tipranavir) are both antiretroviral medications used to treat HIV, but they have some key differences. Kaletra is a combination of two protease inhibitors, lopinavir and ritonavir, and is available in both tablet and oral solution forms. Aptivus, on the other hand, is a single protease inhibitor that must be taken with ritonavir to be effective and is available as capsules and oral solution. Kaletra can be taken once or twice daily, while Aptivus requires twice-daily dosing. Kaletra is suitable for children as young as 2 weeks old, whereas Aptivus is only for children who weigh at least 36 kilograms (79 pounds). Kaletra has more common side effects like diarrhea and nausea, while Aptivus can cause higher cholesterol and blood sugar levels. Additionally, Aptivus is not recommended for people with sulfa allergies or severe liver problems, whereas Kaletra has broader usage but requires regular blood tests to monitor its effects.
