Compare
Entresto vs. Losartan

Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

• Heart failure in people ages 1 year or older

• Low blood pressure (18%)
• High potassium levels (12%)
• Cough (9%)
• Dizziness (6%)
• Kidney problems (5%)

• Not safe during pregnancy
• Swelling of face, tongue, or throat (angioedema)
• Low blood pressure
• Kidney problems
• High potassium levels

Losartan, also known by the brand name Cozaar, is a first-choice medication that's used to lower blood pressure. It's also shown to protect against stroke in certain people. In addition, this medication can slow down the worsening of kidney problems in certain people with diabetes. Losartan (Cozaar) belongs to the drug class called angiotensin II receptor blockers (ARBs). This medication is taken by mouth once daily and is available as a lower-cost generic. Side effects can include dizziness, fatigue, and upper respiratory infections.

• High blood pressure
• Lower the risk of stroke in people with high blood pressure who have a thickened heart (left ventricular hypertrophy)
• Slow down the worsening of kidney problems in people with Type 2 diabetes and high blood pressure

• Upper respiratory infection (e.g., common cold; 8%)
• Dizziness (3%)
• Stuffy nose (2%)
• Back pain (2%)

• Harm to unborn baby
• Low blood pressure
• Kidney damage
• High potassium levels