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Entresto vs. Lisinopril

Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

• Heart failure in people ages 1 year or older

• Low blood pressure (18%)
• High potassium levels (12%)
• Cough (9%)
• Dizziness (6%)
• Kidney problems (5%)

• Not safe during pregnancy
• Swelling of face, tongue, or throat (angioedema)
• Low blood pressure
• Kidney problems
• High potassium levels

Lisinopril (Zestril) is an angiotensin-converting enzyme inhibitor, or ACE inhibitor. It's used to treat high blood pressure in people 6 years and older. In adults, it's also approved to manage heart failure and to lower the risk of death after a heart attack. Lisinopril (Zestril) comes as a tablet that's taken by mouth once daily. There's also an oral solution available under the brand name Qbrelis. Some side effects include dizziness, cough, and headache.

• High blood pressure in people ages 6 years and older
• Heart failure in adults
• Lowering the risk of death after a heart attack in adults

• Dizziness (up to 19%)
• Low blood pressure (up to 11%)
• Higher creatinine levels (up to 10%)

• Harm to an unborn baby
• Angioedema (swelling)
• Low blood pressure
• Possible worsening of kidney problems
• High potassium levels
• Liver problems