Key takeaways
Darifenacin ER (fromerly branded as Enablex) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they have some differences. Darifenacin is only available in an extended-release form, while tolterodine comes in both immediate-release and extended-release forms. This means you can take tolterodine either once or twice a day, depending on the version, whereas darifenacin is taken once a day. Both medications can cause dry mouth and constipation, but tolterodine might cause less dry mouth compared to darifenacin. Darifenacin is generally not recommended for people 65 or older due to the risk of dizziness and drowsiness, while tolterodine can be used with caution in this age group. Additionally, tolterodine has a known risk of memory problems and a potential link to dementia, which is not mentioned for darifenacin. Both medications are available in lower-cost, generic versions.
