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Ditropan XL vs. Vesicare

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Oxybutynin ER (Ditropan XL) and Solifenacin (Vesicare) are both medications used to treat overactive bladder (OAB), but they have some differences. Oxybutynin ER is available in both short-acting and long-acting forms, as well as in a patch and gel, while Solifenacin is only available as a once-daily tablet or liquid. Oxybutynin ER can be used in children as young as 5 years old, whereas Solifenacin can be used in children as young as 2 years old. Oxybutynin ER tends to cause more side effects like dry mouth, dizziness, and drowsiness compared to Solifenacin, which has milder side effects. Both medications can cause dry mouth and should be used carefully in older adults due to the risk of falls. Additionally, Solifenacin has a rare risk of causing a serious heart rhythm problem called QT prolongation, which is not a noted risk for Oxybutynin ER.

Oxybutynin

 

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Solifenacin

(Vesicare)

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Summary for Ditropan XL

Prescription only

Oxybutynin is used to treat overactive bladder (OAB). Oral oxybutynin is available as a short-acting tablet and solution that is taken 2 to 4 times a day. It also comes as a long-acting tablet that's taken once daily (brand name Ditropan XL). Some common side effects of oxybutynin include dry mouth, constipation, and dizziness. Older adults typically lower doses of this medication to lower the risk for side effects.

Indications for Ditropan XL

  • Overactive bladder
  • Incontinence in children due to a neurologic (brain) condition, such as spina bifida

Pros and Cons for Ditropan XL

Pros

  • Works well to improve symptoms of OAB
  • Available as a convenient, once-daily tablet (Ditropan XL)
  • Can be used in children as young as 5 years old
  • Available as an oral liquid, good for people who have trouble swallowing tablets

Cons

  • Commonly causes dry mouth as a side effect
  • Higher risk of side effects in people age 65 and older
  • Can cause dizziness and drowsiness
  • Shouldn't be used by people who have untreated narrow-angle glaucoma, difficulty urinating, or movement problems with the stomach or intestines

Common Side Effects for Ditropan XL

  • Dry mouth (up to 71%)
  • Dizziness (up to 17%)
  • Constipation (up to 15%)
  • Sleepiness (up to 14%)
  • Nausea (up to 12%)
  • Blurry vision (up to 10%)

Warnings for Ditropan XL

  • Swelling of face, lips, tongue (angioedema)
  • Hallucinations, drowsiness, and confusion
  • Worsening of other conditions
  • Heat exhaustion

Summary for Vesicare

Prescription only

Solifenacin succinate, also known by the brand name Vesicare, is an anticholinergic medication that's used to treating certain bladder problems. The brand-name and generic tablets help treat overactive bladder in adults. A liquid suspension under the brand name Vesicare LS is also available for children with neurogenic detrusor overactivity (NDO) (urinary incontinence due to a neurologic problem). This medication is taken by mouth once per day. The most common side effects are dry mouth and constipation.

Indications for Vesicare

Pros and Cons for Vesicare

Pros

  • Only taken once per day, with or without food
  • Comes as a tablet and a liquid suspension
  • Liquid suspension available for children as young as 2 years old

Cons

  • Commonly causes dry mouth
  • Liquid suspension is brand name only
  • Not a good option for people who have trouble urinating or certain gut problems

Common Side Effects for Vesicare

  • Dry mouth (up to 28% in adults, 8% in children)
  • Constipation (up to 13% in adults, 3% in children)

Warnings for Vesicare

  • Swelling of the face and possible breathing problems (angioedema)
  • Side effects related to the nervous system
  • Caution in people with digestive system problems
  • Caution in people with glaucoma
  • QT prolongation (heart rhythm problem)

Prices with our coupons for Ditropan XL vs. Vesicare

Price Card Drug Icon
Oxybutynin ER30 tablets / 10mg
$12.93$55.97
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Price Card Drug Icon
Solifenacin30 tablets / 10mg
$15.88$204.95
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