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Clotrimazole vs. Ketoconazole

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Clotrimazole (Lotrimin AF) and ketoconazole (Nizoral) are both antifungal creams used to treat skin infections like athlete's foot, ringworm, and jock itch. However, there are some key differences between the two. Clotrimazole is available over the counter, making it easier to access, while ketoconazole requires a prescription. Clotrimazole needs to be applied twice daily, whereas ketoconazole is used just once a day. Additionally, ketoconazole can treat more types of infections, such as tinea versicolor and seborrheic dermatitis, which clotrimazole does not. Clotrimazole is safe for children 2 years and older, but ketoconazole is only approved for adults. Both medications have few side effects, but ketoconazole can cause allergic reactions in people with asthma or sulfite allergies.

Clotrimazole

(Lotrimin)

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ketoconazole cream

 

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Summary for Clotrimazole

Prescription or over-the-counter

Clotrimazole (Lotrimin) is an antifungal medication used to treat certain skin fungal infections. A healthcare professional might also prescribe it for diaper rash. It's available over the counter (OTC) and by prescription as a cream or topical solution that you apply to your skin. You usually use it two times a day for a few weeks, depending on the infection. The most common side effect is skin irritation.

Indications for Clotrimazole

Pros and Cons for Clotrimazole

Pros

  • Applied directly to the affected area(s)
  • Can treat multiple fungal skin infections
  • Safe for both adults and children

Cons

  • Need to apply twice daily
  • Must use every day for several weeks
  • Can cause mild skin irritation

Common Side Effects for Clotrimazole

  • Skin irritations (e.g., itching, redness)

Warnings for Clotrimazole

  • Use only on your skin

Summary for Ketoconazole

Prescription only

Ketoconazole cream is an antifungal medication. It's used to treat different types of fungal skin infections, including ringworm and yeast skin infections. Ketoconazole cream is approved for adults only. It's typically applied onto the skin once or twice a day. Most people have very few side effects, like itching and stinging where the cream is applied.

Indications for Ketoconazole

Pros and Cons for Ketoconazole

Pros

  • Can treat many different kinds of fungal skin infections
  • Skin usually starts improving shortly after you start using the cream
  • Applied directly to the affected area(s)
  • Has few side effects

Cons

  • Must use for at least 2 weeks (depends on the type of infection)
  • Not available over the counter
  • Some creams have sulfites, which can cause allergic reactions in certain people
  • Not known if safe for people who are pregnant or breastfeeding

Common Side Effects for Ketoconazole

  • Itchiness (5%)
  • Skin irritation (5%)
  • Stinging (5%)

Warnings for Ketoconazole

  • Allergic reaction

Prices with our coupons for Clotrimazole vs. Ketoconazole

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Clotrimazole1 tube / 30g of 1%
$13.93$47.54
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Ketoconazole1 tube / 60g of 2%
$19.62$76.62
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