Depression Medications

Popular Depression Drugs

Popularity Drug Name Drug Class Price Price Trend
SSRIs 9
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Sertraline (Zoloft) is an inexpensive drug used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD), or social anxiety. It is more popular than comparable drugs. Generic sertraline is is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 7
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Fluoxetine (Prozac) is an inexpensive drug used to treat mood problems such as depression, obsessive compulsive disorder, and panic attacks. It can also treat certain eating disorders. It is available in generic and brand versions. Generic fluoxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Atypical Antidepressants 7
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Trazodone (Desyrel, Trialodine) is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 10
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Escitalopram (Lexapro) is an inexpensive drug used to treat depression and certain types of anxiety. This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 7
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CITALOPRAM is a medicine for depression.
SNRIs 17
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Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. Generic duloxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SNRIs 11
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Effexor XR (venlafaxine ER) is an extended-release SNRI used to treat depression, anxiety, and panic disorder. It works by increasing the amount of serotonin and norepinephrine available in the brain. Effexor XR is available as generic venlafaxine ER. Immediate release venlafaxine is also available, though regular Effexor has been discontinued.
Atypical Antidepressants 19
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Bupropion (bupropion XL, Wellbutrin XL, budeprion XL) is a moderately priced drug used to treat depression. This drug is slightly more popular than comparable drugs. It is available in multiple brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Tricyclic Antidepressants 10
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AMITRIPTYLINE is used to treat depression.
Atypical Antidepressants 17
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BUPROPION is used to treat depression.
SSRIs 9
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
Atypical Antidepressants 10
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MIRTAZAPINE is used to treat depression.
Atypical Antipsychotics 44
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Aripiprazole (Abilify) is an expensive drug used to treat schizophrenia and bipolar disorder, also known as manic-depression. It is also used to treat Tourette's disorder and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat major depressive disorder. This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Tricyclic Antidepressants 9
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NORTRIPTYLINE is used to treat depression.
SNRIs 21
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Venlafaxine is a generic SNRI used to treat depression. It works by increasing the amount of serotonin and norepinephrine available in the brain. Brand name venlafaxine was known as Effexor and has been discontinued. An extended release version, Effexor XR (venlafaxine ER) is available as a brand and generic.
Atypical Antidepressants 24
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BUPROPION is used to treat depression.
Tricyclic Antidepressants 14
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DOXEPIN is used to treat depression and anxiety.
SNRIs 49
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Desvenlafaxine (Pristiq) is an expensive drug used to treat depression. This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Atypical Antidepressants 329
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Trintellix (vortioxetine) is used to treat depression. Trintellix is less popular than other atypical antidepressants. There are currently no generic alternatives to Trintellix.

Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Trintellix is covered by some Medicare and insurance plans.

SSRIs 219
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Vilazodone (Viibryd) is an expensive drug used to treat depression. This drug is less popular than comparable drugs. There are currently no generic alternatives to Viibryd. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Tricyclic Antidepressants 12
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IMIPRAMINE is used to treat depression. This medicine can also help children who have a nighttime bed wetting problem.
Atypical Antipsychotics 34
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QUETIAPINE is an antipsychotic. It is used to treat schizophrenia and bipolar disorder, also known as manic-depression. It is also used to treat major depression in combination with antidepressants.
SSRIs 68
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
Tricyclic Antidepressants 21
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DESIPRAMINE is used to treat depression.
Atypical Antipsychotics 1,038
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BREXPIPRAZOLE is an antipsychotic. It is used to treat schizophrenia. This medicine is also used in combination with antidepressants to treat major depressive disorder.
SNRIs 342
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Levomilnacipran is used to treat depression.
Atypical Antidepressants 68
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NEFAZODONE is used to treat depression.
Medical Foods 157
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LEVOMEFOLATE is a medical food. It is used together with medicines to manage depression and schizophrenia.
Typical Antipsychotic / Tricyclic Antidepressant Combinations 70
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PERPHENAZINE; AMITRIPTYLINE is used to treat depression that may be accompanied by anxiety or agitation. This medicine is also used to treat schizophrenia.
Benzodiazepine / Tricyclic Antidepressant Combinations 44
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AMITRIPTYLINE; CHLORDIAZEPOXIDE is an anti-depressant and a benzodiazepine. It is used to treat depression with anxiety.
Atypical Antidepressants 452
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BUPROPION is used to treat depression.
MAOIs 47
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PHENELZINE is a monoamine oxidase inhibitor (MAOI). It is used to treat depression in patients who may also have anxiety. This medicine is usually only used when other medicines have not helped.
Tricyclic Antidepressants 44
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PROTRIPTYLINE is used to treat depression.
SNRIs 256
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DESVENLAFAXINE is used to treat depression.
MAOIs 1,691
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SELEGILINE is an monoamine oxidase inhibitor (MAOI). It is used to treat major depression.
Atypical Antipsychotic / SSRI Combinations 181
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FLUOXETINE; OLANZAPINE is used to treat episodes of depression that have not been relieved by the use of other medicines and depression caused by bipolar disorder.
Tricyclic Antidepressants 188
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IMIPRAMINE is used to treat depression.
MAOIs 338
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TRANYLCYPROMINE is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.
Tricyclic Antidepressants 22
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AMOXAPINE is used to treat depression.
Tricyclic Antidepressants 32
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MAPROTILINE is used to treat depression. This medicine also helps to relieve anxiety associated with depression.
SSRIs 395
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
Atypical Antidepressants 1,226
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BUPROPION is used to treat depression.
SNRIs 132
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Atypical Antidepressants 107
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TRAZODONE is used to treat depression.
Tricyclic Antidepressants 302
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TRIMIPRAMINE is used to treat depression.
MAOIs 272
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ISOCARBOXAZID is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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