Popular Depression Drugs

Popularity Drug Name Drug Class Price Price Trend
SSRIs 9
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Sertraline (Zoloft) is an inexpensive drug used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD), or social anxiety. It is more popular than comparable drugs. Generic sertraline is is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 6
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Fluoxetine (Prozac) is an inexpensive drug used to treat mood problems such as depression, obsessive compulsive disorder, and panic attacks. It can also treat certain eating disorders. It is available in generic and brand versions. Generic fluoxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Atypical Antidepressants 7
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Trazodone (Desyrel, Trialodine) is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 7
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CITALOPRAM is a medicine for depression.
SSRIs 12
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Escitalopram (Lexapro) is an inexpensive drug used to treat depression and certain types of anxiety. This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SNRIs 17
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Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. Generic duloxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SNRIs 11
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Effexor XR (venlafaxine ER) is an extended-release SNRI used to treat depression, anxiety, and panic disorder. It works by increasing the amount of serotonin and norepinephrine available in the brain. Effexor XR is available as generic venlafaxine ER. Immediate release venlafaxine is also available, though regular Effexor has been discontinued.
Atypical Antidepressants 19
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Bupropion (bupropion XL, Wellbutrin XL, budeprion XL) is a moderately priced drug used to treat depression. This drug is slightly more popular than comparable drugs. It is available in multiple brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Tricyclic Antidepressants 9
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AMITRIPTYLINE is used to treat depression.
Atypical Antidepressants 16
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BUPROPION is used to treat depression.
SSRIs 9
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
Atypical Antidepressants 11
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MIRTAZAPINE is used to treat depression.
Atypical Antipsychotics 101
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Aripiprazole (Abilify) is an expensive drug used to treat schizophrenia and bipolar disorder, also known as manic-depression. It is also used to treat Tourette's disorder and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat major depressive disorder. This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Tricyclic Antidepressants 8
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NORTRIPTYLINE is used to treat depression.
SNRIs 25
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Venlafaxine is a generic SNRI used to treat depression. It works by increasing the amount of serotonin and norepinephrine available in the brain. Brand name venlafaxine was known as Effexor and has been discontinued. An extended release version, Effexor XR (venlafaxine ER) is available as a brand and generic.
Atypical Antidepressants 23
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BUPROPION is used to treat depression.
Tricyclic Antidepressants 11
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DOXEPIN is used to treat depression and anxiety.
SNRIs 299
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Desvenlafaxine (Pristiq) is an expensive drug used to treat depression. This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
SSRIs 216
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Vilazodone (Viibryd) is an expensive drug used to treat depression. This drug is less popular than comparable drugs. There are currently no generic alternatives to Viibryd. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Atypical Antidepressants 326
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Vortioxetine is used to treat depression.
Tricyclic Antidepressants 8
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IMIPRAMINE is used to treat depression. This medicine can also help children who have a nighttime bed wetting problem.
SSRIs 76
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
Atypical Antipsychotics 647
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QUETIAPINE is an antipsychotic. It is used to treat schizophrenia and bipolar disorder, also known as manic-depression. It is also used to treat major depression in combination with antidepressants.
Tricyclic Antidepressants 27
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DESIPRAMINE is used to treat depression.
SNRIs 307
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Levomilnacipran is used to treat depression.
Atypical Antipsychotics 944
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BREXPIPRAZOLE is an antipsychotic. It is used to treat schizophrenia. This medicine is also used in combination with antidepressants to treat major depressive disorder.
Atypical Antidepressants 60
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NEFAZODONE is used to treat depression.
Medical Foods 142
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LEVOMEFOLATE is a medical food. It is used together with medicines to manage depression and schizophrenia.
Typical Antipsychotic / Tricyclic Antidepressant Combinations 130
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PERPHENAZINE; AMITRIPTYLINE is used to treat depression that may be accompanied by anxiety or agitation. This medicine is also used to treat schizophrenia.
Benzodiazepine / Tricyclic Antidepressant Combinations 40
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AMITRIPTYLINE; CHLORDIAZEPOXIDE is an anti-depressant and a benzodiazepine. It is used to treat depression with anxiety.
Atypical Antidepressants 368
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BUPROPION is used to treat depression.
MAOIs 58
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PHENELZINE is a monoamine oxidase inhibitor (MAOI). It is used to treat depression in patients who may also have anxiety. This medicine is usually only used when other medicines have not helped.
Atypical Antipsychotic / SSRI Combinations 234
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FLUOXETINE; OLANZAPINE is used to treat episodes of depression that have not been relieved by the use of other medicines and depression caused by bipolar disorder.
Tricyclic Antidepressants 27
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PROTRIPTYLINE is used to treat depression.
Tricyclic Antidepressants 163
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IMIPRAMINE is used to treat depression.
MAOIs 1,524
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SELEGILINE is an monoamine oxidase inhibitor (MAOI). It is used to treat major depression.
MAOIs 362
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TRANYLCYPROMINE is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.
Tricyclic Antidepressants 225
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MAPROTILINE is used to treat depression. This medicine also helps to relieve anxiety associated with depression.
SNRIs 256
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DESVENLAFAXINE is used to treat depression.
Tricyclic Antidepressants 19
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AMOXAPINE is used to treat depression.
Atypical Antidepressants 3,575
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BUPROPION is used to treat depression.
SSRIs 355
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PAROXETINE is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD).
MAOIs 128
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ISOCARBOXAZID is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.
Tricyclic Antidepressants 221
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TRIMIPRAMINE is used to treat depression.
SNRIs 152
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DESVENLAFAXINE is used to treat depression.
Atypical Antidepressants 105
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TRAZODONE is used to treat depression.
SNRIs N/A N/A See Prices

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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GoodRx is not sponsored by or affiliated with any of the pharmacies identified in its price comparisons. All trademarks, brands, logos and copyright images are property of their respective owners and rights holders and are used solely to represent the products of these rights holders. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any of the pricing data or other information. Please seek medical advice before starting, changing or terminating any medical treatment.