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Chlordiazepoxide / Amitriptyline Coupon - Chlordiazepoxide / Amitriptyline 5mg/12.5mg tablet

chlordiazepoxide / amitriptyline

Generic Limbitrol
Used for Depression, Anxiety
Used for Depression, Anxiety

Chlordiazepoxide/amitriptyline is a combination medication containing chlordiazepoxide and amitriptyline. It treats depression related to anxiety, but it's not a first-choice treatment option.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
Michelle Nguyen, PharmD
Last reviewed on September 23, 2021
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageInteractionsCostContraindicationsAlternativesImagesPricesMedicare
Chlordiazepoxide/amitriptyline is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Chlordiazepoxide/amitriptyline?

What is Chlordiazepoxide/amitriptyline used for?

  • Depression related to anxiety

How Chlordiazepoxide/amitriptyline works

Chlordiazepoxide/amitriptyline is a combination of two medications that affect your mood.

  • Chlordiazepoxide is a benzodiazepine. It slows down activity in your brain to help control anxiety.

  • Amitriptyline is a tricyclic antidepressant. It raises the levels of norepinephrine and serotonin, which are natural chemicals in your brain that can improve your mood.

Are you looking for information on chlordiazepoxide or amitriptyline instead?

Drug Facts

Common BrandsLimbitrol (brand no longer available)
Drug ClassBenzodiazepine / Tricyclic antidepressant
Controlled Substance ClassificationSchedule IV
Generic StatusLower-cost generic available
AvailabilityPrescription only
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$50.15(save 61.66%)
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$19.23
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What are the risks and warnings for Chlordiazepoxide/amitriptyline?

Chlordiazepoxide/amitriptyline can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Risks while also taking opioids

  • Risk factors: Taking chlordiazepoxide/amitriptyline with opioids

    Combining chlordiazepoxide/amitriptyline with certain pain medications called opioids can cause a life-threatening interaction that may cause you to be extremely sleepy or stop breathing. It's very important not to combine chlordiazepoxide/amitriptyline with opioids unless you're under close supervision of a healthcare provider. Get emergency help if you feel like you are having trouble breathing or can't wake up very easily after taking chlordiazepoxide/amitriptyline. Educate those around you to keep an eye out for these side effects as well.

    risk-warning

    Abuse, misuse, dependence, and withdrawal

    • Risk factors: History of substance misuse | Taking with alcohol or certain medications | Taking chlordiazepoxide/amitriptyline for a long time | Stopping chlordiazepoxide/amitriptyline suddenly

      Chlordiazepoxide/amitriptyline is a controlled medication because there's a high risk for abuse and misuse. Your body can also become dependent on the medication, even if you're taking it exactly as directed. Taking chlordiazepoxide/amitriptyline short term can lower these risks. If you have been taking it for a long time, talk to your provider before stopping. Stopping the medication suddenly can lead to serious medical problems, including seizures.

      risk-warning

      Suicidal thoughts and behavior

      • Risk factors: Age 24 or younger

        Chlordiazepoxide/amitriptyline can raise the risk of suicidal thoughts or behavior. Watch for new or worsening depression, suicidal thoughts or behavior, especially during the first few months of treatment or when your dose changes. Let your healthcare provider know right away if you notice any unusual changes in your mood or behavior while taking this medication.

        risk-warning

        Bipolar disorder

        Sometimes depression can be the first sign of bipolar disorder. Unfortunately, chlordiazepoxide/amitriptyline doesn't treat bipolar and can cause a manic phase. Your provider will screen you for bipolar disorder before starting chlordiazepoxide/amitriptyline. Let them know your full medical history and if anyone in your family has a history of bipolar disorder.

        risk-warning

        Eye problems

        • Risk factors: Narrow-angle glaucoma

          Many antidepressants, including chlordiazepoxide/amitriptyline, can cause eye-related side effects. This can cause eye pain in people who have underlying conditions, such as glaucoma. Let your provider know if you have a history of eye problems and if the medication starts causing vision changes or discomfort.

          risk-warning

          Heart problems

          • Risk factors: History of heart conditions | Taking high doses of chlordiazepoxide/amitriptyline

            Chlordiazepoxide/amitriptyline contains a tricyclic antidepressant, which can cause heart problems, including irregular heart rhythms, heart attack, or stroke. It's more likely to happen if you take higher doses of chlordiazepoxide/amitriptyline and if you have a history of heart conditions.

            basics-icon

            What are the side effects of Chlordiazepoxide/amitriptyline?

            The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

            Common Side Effects

            • Feeling drowsy or sleepy
            • Dizziness
            • Dry mouth
            • Constipation
            • Bloating
            • Blurry vision

            Other Side Effects

            • Vivid dreams
            • Sexual dysfunction
            • Shakiness, tremor
            • Confusion
            • Congested or runny nose

            Serious Side Effects

            Contact your healthcare provider immediately if you experience any of the following.
            • Extreme sleepiness
            • Slowed breathing
            • Suicidal thoughts or behaviors

            Source: DailyMed

            The following side effects have also been reported

            Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

            Check with your doctor immediately if any of the following side effects occur:

            Less common

            Blurred vision or other changes in vision

            confusion

            constipation

            difficulty in urinating

            dizziness or lightheadedness

            eye pain

            fainting

            irregular heartbeat

            irritability

            mental depression

            nervousness

            seeing, hearing, or feeling things that are not there

            shakiness

            talking, feeling, and acting with excitement

            trouble in sleeping

            Incidence not known

            Actions that are out of control

            chest pain or discomfort

            decreased interest in sexual intercourse

            false or unusual sense of well-being

            fast, slow, or irregular heartbeat

            inability to have or keep an erection

            increased in sexual ability, desire, drive, or performance

            increased interest in sexual intercourse

            increased sensitivity to sunlight

            loss in sexual ability, desire, drive, or performance

            pain or discomfort in the arms, jaw, back or neck

            redness or other discoloration of skin

            severe sunburn

            shakiness and unsteady walk

            skin rash

            sore throat and fever

            sweating

            swelling of the breasts or breast soreness in males

            swelling of the testicles

            swelling or inflammation of the mouth

            unexpected or excess milk flow from breasts

            unsteadiness, trembling, or other problems with muscle control or coordination

            Get emergency help immediately if any of the following symptoms of overdose occur:

            Symptoms of overdose

            Disorientation

            dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

            headache

            loss of consciousness

            mood or other mental changes

            seizures

            trouble breathing, unusual tiredness or weakness

            unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

            Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

            More common

            Bloating

            clumsiness or unsteadiness

            dryness of mouth or unpleasant taste

            weight gain

            Less common

            Diarrhea

            nausea or vomiting

            Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

            Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

            pros-and-cons

            Pros and cons of Chlordiazepoxide/amitriptyline

            thumbs-up

            Pros

            Contains two medications in one

            Works faster than amitriptyline alone

            Available in a lower-cost generic

            thumbs-down

            Cons

            Controlled medication; risk of abuse and misuse

            Not a first-choice treatment option

            Can cause a lot of side effects

            pharmacist-tips

            Pharmacist tips for Chlordiazepoxide/amitriptyline

            pharmacist

            • It's going to take time for your body to get used to the medication. Taking small doses throughout the day can help. Eventually, you might be able to manage your depression and anxiety with one dose a day, taken at bedtime.

              • If you've been taking chlordiazepoxide/amitriptyline for a while, don't suddenly stop taking it unless your provider tells you to. Suddenly stopping chlordiazepoxide/amitriptyline can cause withdrawal symptoms.

                • Common side effects include sleepiness, dizziness, and vision changes. Don't drive or do anything that requires you to focus until you know how this medication affects you.

                  • Dry mouth is a common side effect. Drinking water, sucking on ice cubes or hard candy, and chewing gum can help with this.

                    • Store this medication in a safe place. Get medical help or call poison control at 1-800-222-1222 right away if a child accidentally takes it or if anyone takes too much.

                      faqs

                      Frequently asked questions about Chlordiazepoxide/amitriptyline

                      When will I feel the effects of chlordiazepoxide/amitriptyline?
                      You can start to feel the effects of chlordiazepoxide/amitriptyline within the first week of starting the medication. Mood symptoms that usually get better first include insomnia (trouble sleeping), feeling guilty or worthless, anxiety, and anorexia (loss of appetite).
                      Is chlordiazepoxide/amitriptyline addictive?
                      Yes, chlordiazepoxide/amitriptyline contains chlordiazepoxide, a benzodiazepine that can be addictive. This is one of the reasons why chlordiazepoxide/amitriptyline isn't a first-choice treatment option.
                      Can I drink alcohol with chlordiazepoxide/amitriptyline?
                      Avoid alcohol while you're taking chlordiazepoxide/amitriptyline. The combination can make you very tired and has the potential to cause serious breathing problems, which can be fatal.
                      Is chlordiazepoxide/amitriptyline a sleeping pill?
                      No, chlordiazepoxide/amitriptyline isn't a sleeping pill. It can help you sleep if your insomnia is caused by your anxiety and depression. However, if you're looking for a sleeping medication, there might be better options.
                      Does chlordiazepoxide/amitriptyline cause weight gain?
                      Weight gain isn't common with chlordiazepoxide/amitriptyline. Still, some people experience weight gain or weight loss with medications that work like amitriptyline. So weight gain might be possible.
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                      dosage

                      Chlordiazepoxide/amitriptyline dosage forms

                      The average cost for 30 tablets of 5mg/12.5mg of Chlordiazepoxide/amitriptyline is $19.23 with a free GoodRx coupon. This is 61.66% off the average retail price of $50.15.
                      tablet
                      Tablet
                      DosageQuantityPrice as low asPrice per unit
                      5mg/12.5mg30 tablets$19.23$0.64
                      10mg/25mg30 tablets$23.35$0.78

                      Typical dosing for Chlordiazepoxide/amitriptyline

                      The typical starting dose is 10 mg/25 mg (chlordiazepoxide/amitriptyline) by mouth 2 to 4 times a day. The maximum total dose for one day is 60 mg/150 mg (chlordiazepoxide/amitriptyline).

                      interactions

                      Interactions between Chlordiazepoxide/amitriptyline and other drugs

                      Chlordiazepoxide/amitriptyline may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Chlordiazepoxide/amitriptyline. Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                      How much does Chlordiazepoxide/amitriptyline cost?

                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                      Chlordiazepoxide/amitriptyline (generic)
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                      contraindications-icon

                      Chlordiazepoxide/amitriptyline contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Chlordiazepoxide/amitriptyline will not be safe for you to take.

                      • Taking a monoamine oxidase inhibitor (MAOI) medication in the last 14 days

                      • Recent heart attack

                      alternatives

                      What are alternatives to Chlordiazepoxide/amitriptyline?

                      There are a number of medications that your doctor can prescribe in place of Chlordiazepoxide/amitriptyline. Compare a few possible alternatives below.
                      Chlordiazepoxide/amitriptyline
                      Used for:

                      • Depression related to anxiety

                      $19.23 Lowest GoodRx priceView Prices
                      Sertraline (Zoloft)
                      Used for:
                      $9.60 Lowest GoodRx priceView Prices
                      Duloxetine (Cymbalta)
                      Used for:
                      $10.20 Lowest GoodRx priceView Prices
                      images

                      Chlordiazepoxide/amitriptyline images

                      Green-Yellow Round Mylan And 211 - Chlordiazepoxide Hydrochloride / Amitriptyline Hydrochloride 5mg-12.5mg Tablet
                      This medicine is Green-Yellow, Round Tablet Imprinted With "Mylan" And "211".Green-Yellow Round Mylan And 211 - Chlordiazepoxide Hydrochloride / Amitriptyline Hydrochloride 5mg-12.5mg Tablet

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